多层螺旋CT灌注成像评价介入性热化疗治疗中晚期肝癌的价值

doi:10.7517/issn.1674-0475.190909

影像科学与光化学 ›› 2020, Vol. 38 ›› Issue (2): 272-279.DOI: 10.7517/issn.1674-0475.190909

多层螺旋CT灌注成像评价介入性热化疗治疗中晚期肝癌的价值

陈庭宇¹, 王涛², 龚齐云³, 王恒², 张洪伟²

1. 四川大学华西医院放射科, 四川成都 610041;
2. 四川大学华西医院肝脏外科, 四川成都 610041;
3. 成都市第五人民医院放射科, 四川成都 610041

收稿日期:2019-09-15 出版日期:2020-03-15 发布日期:2020-03-15
基金资助:
四川省医学科学研究课题（16PJ009）资助

Value of Multi-slice Spiral CT Perfusion Imaging in Evaluating Interventional Thermochemotherapy for Advanced Hepatocellular Carcinoma

CHEN Tingyu¹, WANG Tao², GONG Qiyun³, WANG Heng², ZHANG Hongwei²

1. Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, P. R. China;
2. Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, P. R. China;
3. Department of Radiology, Chengdu Fifth People's Hospital, Chengdu 610041, Sichuan, P. R. China

Received:2019-09-15 Online:2020-03-15 Published:2020-03-15
Supported by:

摘要/Abstract

摘要： 为探讨多层螺旋CT灌注成像（CT perfusion imaging，CTPI）在评价介入性热化疗对中晚期肝癌疗效方面的应用价值，本文分析了72例采用介入性热化疗的中晚期肝癌患者在治疗前后的CTPI灌注参数和血清肿瘤学标志物水平。通过与治疗前数据比较，发现治疗后癌灶区CTPI灌注参数明显改善，血清肿瘤标志物明显降低。CTPI灌注参数、血清肿瘤学标志物在碘油完全沉积和部分沉积组、客观缓解和未缓解组均表现出显著的统计学差异。Pearson相关分析结果显示CTPI灌注参数与肝癌血清肿瘤标志物之间存在显著相关性。由此可见，CTPI灌注参数可有效反映介入性热化疗前后晚期肝癌患者的动脉血供变化，为临床疗效评估提供有价值的参考。

关键词: 多层螺旋CT灌注成像, 介入性热化疗, 肝癌, 客观缓解, AFP, VEGF, MMP-9

Abstract: To investigate the application value of multi-slice spiral CT perfusion imaging (CTPI) in evaluating the efficacy of interventional thermal chemotherapy in the treatment of advanced liver cancer, we analyzed the CTPI perfusion parameters and serum oncology markers of 72 patients with middle and advanced liver cancer before and after interventional thermochemotherapy treatment. Compared with the data before treatment, it was found that the perfusion parameters of CTPI in the cancer foci were significantly improved after treatment, and the serum tumor markers were significantly decreased. The CTPI perfusion parameters and serum tumor markers showed statistically significant differences between the complete lipiodol depositon group and partial lipiodol depositon group, the same as between the objective remission group and non-remission group. Pearson correlation analysis showed a significant correlation between CTPI perfusion parameters and serum tumor markers of liver cancer patients. In conclusion, CTPI perfusion parameters can effectively reflect arterial blood supply changes in patients with advanced liver cancer before and after interventional thermal chemotherapy, providing a valuable reference for clinical efficacy evaluation.

Key words: multi-slice spiral CT perfusion imaging, interventional thermochemotherapy, liver cancer, objective remission, AFP, VEGF, MMP-9

中图分类号:

陈庭宇, 王涛, 龚齐云, 王恒, 张洪伟. 多层螺旋CT灌注成像评价介入性热化疗治疗中晚期肝癌的价值[J]. 影像科学与光化学, 2020, 38(2): 272-279.

CHEN Tingyu, WANG Tao, GONG Qiyun, WANG Heng, ZHANG Hongwei. Value of Multi-slice Spiral CT Perfusion Imaging in Evaluating Interventional Thermochemotherapy for Advanced Hepatocellular Carcinoma[J]. Imaging Science and Photochemistry, 2020, 38(2): 272-279.

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多层螺旋CT灌注成像评价介入性热化疗治疗中晚期肝癌的价值

Value of Multi-slice Spiral CT Perfusion Imaging in Evaluating Interventional Thermochemotherapy for Advanced Hepatocellular Carcinoma

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