基于双源CT血管造影技术评估MMP-9、PAF及Lp-PLA2与冠状动脉斑块性质的关系

doi:10.7517/issn.1674-0475.190913

影像科学与光化学 ›› 2020, Vol. 38 ›› Issue (2): 291-295.DOI: 10.7517/issn.1674-0475.190913

基于双源CT血管造影技术评估MMP-9、PAF及Lp-PLA2与冠状动脉斑块性质的关系

刘峰^1,2,3, 邓大平^1,2

1. 济南大学山东省医学科学与生命科学学院, 山东济南 250062;
2. 山东省医学科学院放射医学研究所, 山东济南 250062;
3. 泰山医学院附属新泰市人民医院影像科, 山东新泰 271200

收稿日期:2019-09-17 出版日期:2020-03-15 发布日期:2020-03-15
基金资助:
山东省优秀中青年科学家科研奖励基金（BS2015SW174）项目资助

Evaluation of the Relationship Between MMP-9, PAF, Lp-PLA2 and Coronary Plaque Properties Based on Dual-source CT Angiography

LIU Feng^1,2,3, DENG Daping^1,2

1. Institute of Radiology, Shandong Academy of Medical Sciences, Jinan 250062, Shandong, P. R. China;
2. Shandong College of Medical Sciences and Life Sciences, Jinan University, Jinan 250062, Shandong, P. R. China;
3. Department of Imaging, Xintai People's Hospital, Taishan Medical College, Xintai 271200, Shandong, P. R. China

Received:2019-09-17 Online:2020-03-15 Published:2020-03-15
Supported by:

摘要/Abstract

摘要： 冠状动脉粥样硬化性心脏病是威胁健康的常见病之一，本研究选取我院2017年2月~2018年12月确诊的206例冠心病患者，其中急性冠脉综合征（acute coronary syndrome，ACS）患者114例（ACS组）、稳定型心绞痛（stable angina pectoris，SAP）患者92例（SAP组），用双源CT血管造影技术检测患者的斑块性质，并检测了血清明胶酶B（MMP-9）、血小板活化因子（PAF）及脂蛋白相关磷脂酶2（Lp-PLA2）浓度，分析MMP-9、PAF及Lp-PLA2与斑块性质间的关系。结果显示，ACS组患者斑块面积和偏心指数均大于SAP组（P<0.05）；ACS组患者血清MMP-9、PAF及Lp-PLA2的水平均高于SAP组（P<0.05）；ACS组患者易损斑块的比例明显高于SAP组（P<0.05）。所有易损斑块患者血清MMP-9、PAF及Lp-PLA2的水平均高于稳定斑块的患者，且差异具有统计学意义（P<0.05）。患者冠状动脉斑块偏心指数与血清MMP-9、PAF及Lp-PLA2浓度呈正相关关系（P<0.05）。因此，通过双源CT血管造影技术观察冠状动脉粥样硬化斑块性质，结合血清MMP-9、PAF及Lp-PLA2浓度，可以对患者的病情进行评估。血清MMP-9、PAF及Lp-PLA2浓度与斑块的性质及不稳定性有关，可为预测患者冠状动脉斑块性质提供参考。

关键词: 双源CT血管造影技术, MMP-9, PAF, Lp-PLA2, 冠状动脉斑块

Abstract: Coronary atherosclerotic heart disease is one of the common diseases that threaten health. In this study, I selected 206 patients with coronary heart disease diagnosed in our hospital from February 2017 to December 2018. Among them, there were 114 patients of acute coronary syndrome(ACS group) and 92 patients of stable angina pectoris(SAP group). The plaque properties of the patients were detected by dual-source CT angiography. The concentrations of serum MMP-9, PAF and Lp-PLA2 were measured in the laboratory, and the relationship between MMP-9, PAF, Lp-PLA2 and plaque properties was analyzed. The results showed that the plaque area and eccentricity index of the patients in the ACS group were larger than those in the SAP group (P<0.05). The levels of serum MMP-9, PAF and Lp-PLA2 in the ACS group were higher than those in the SAP group (P<0.05). The proportion of vulnerable plaques in the ACS group was significantly higher than that in the SAP group (P<0.05). The levels of serum MMP-9, PAF and Lp-PLA2 in all vulnerable plaques were higher than those in stable plaques, and the difference was statistically significant (P<0.05). The eccentricity index of coronary plaque was positively correlated with serum MMP-9, PAF and Lp-PLA2 concentrations (P<0.05). Therefore, the observation of coronary atherosclerotic plaque by dual-source CT angiography and serum MMP-9, PAF and Lp-PLA2 levels can be used to assess the patient's condition. Serum MMP-9, PAF and Lp-PLA2 concentrations are related to the nature and instability of plaque, which can provide a basis for predicting the nature of coronary plaque in patients.

Key words: dual-source CT angiography, MMP-9, PAF, Lp-PLA2, coronary plaque

中图分类号:

刘峰, 邓大平. 基于双源CT血管造影技术评估MMP-9、PAF及Lp-PLA2与冠状动脉斑块性质的关系[J]. 影像科学与光化学, 2020, 38(2): 291-295.

LIU Feng, DENG Daping. Evaluation of the Relationship Between MMP-9, PAF, Lp-PLA2 and Coronary Plaque Properties Based on Dual-source CT Angiography[J]. Imaging Science and Photochemistry, 2020, 38(2): 291-295.

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基于双源CT血管造影技术评估MMP-9、PAF及Lp-PLA2与冠状动脉斑块性质的关系

Evaluation of the Relationship Between MMP-9, PAF, Lp-PLA2 and Coronary Plaque Properties Based on Dual-source CT Angiography

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