床旁颅脑超声结合振幅整合脑电图检查在早产儿脑功能发育状态评估中的应用价值

doi:10.7517/issn.1674-0475.191112

摘要/Abstract

摘要： 为探讨床旁颅脑超声结合振幅整合脑电图检查对早产儿脑功能发育状态的评估作用，本研究选取2017年6月~2019年4月我院新生儿重症监护病房收治的早产儿100例，根据临床诊断有无脑损伤，将患儿分为脑损伤组（42例）和无脑损伤组（58例），两组患儿均给予床旁颅脑超声和振幅整合脑电图检查，比较其检查结果，活动睡眠期（AS）和安静睡眠期（QS）振幅电压变化，绘制ROC曲线，分析床旁颅脑超声检查、振幅整合脑电图检查，以及联合检查对早产儿脑损伤的诊断效能。结果显示，脑损伤组超声检查异常率、振幅异常检出率均明显高于无脑损伤组（P<0.05）；脑损伤组连续性电压、睡眠周期性检出率，以及AS和QS期振幅电压均明显低于无脑损伤组（P<0.05）。ROC曲线分析表明：床旁颅脑超声结合振幅整合脑电图检查对早产儿脑损伤诊断的敏感性、特异性均明显高于单一检查（P<0.05）。床旁颅脑超声检查可反映早产儿脑实质发育情况，振幅整合脑电图检查可反映早产儿脑功能发育情况，两者联合检查对早产儿脑损伤有较好的评估作用。

关键词: 早产儿, 床旁颅脑超声, 振幅整合脑电图, 脑发育, 脑损伤

Abstract: To investigate the effect of bedside cranial ultrasound combined with amplitude-integrated electroencephalogram (aEEG) on the development of brain function in preterm infants, 100 premature infants were selected on NICU from June 2017 to April 2019, in this study. According to the clinical diagnosis of brain injury, the children were divided into brain injury group (42 cases) and non brain injury group (58 cases). Two groups of children were given bedside cranial ultrasound and aEEG examination.The changes of amplitude voltage of AS and QS were compared between the two groups. To draw ROC curve and analyze the diagnostic efficacy of bedside cranial ultrasound, aEEG and their joint examination on brain injury of premature infants. The results show that, the abnormal rate of ultrasonic examination and the abnormal detection rate of amplitude in brain injury group were significantly higher than those in non brain injury group (P<0.05). The continuous voltage, the periodic detection rate of sleep and the amplitude voltage of AS and QS in brain injury group were significantly lower than those in non brain injury group (P<0.05). ROC curve analysis showed that, the sensitivity and specificity of bedside cranial ultrasound combined with aEEG were significantly higher than that of single examination (P<0.05). Therefore, bedside brain ultrasound can reflect the development status of brain parenchyma and aEEG can reflect the development status of brain function of preterm infants. The combined examination has a better effect for evaluation the brain injury of premature infants.

Key words: premature infant, bedside cranial ultrasound, amplitude-integrated electroencephalogram (aEEG), brain development, brain injury

李菊华, 杨昕辰. 床旁颅脑超声结合振幅整合脑电图检查在早产儿脑功能发育状态评估中的应用价值[J]. 影像科学与光化学, 2020, 38(3): 482-486.

LI Juhua, YANG Xinchen. The Value of Bedside Cranial Ultrasound Combined with Amplitude-integrated Electroencephalogram in the Assessment of Brain Function and Development of Premature Infants[J]. Imaging Science and Photochemistry, 2020, 38(3): 482-486.

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