甲状腺微小乳头状癌中央区淋巴结转移复发相关因素研究分析

doi:10.7517/issn.1674-0475.200409

影像科学与光化学 ›› 2020, Vol. 38 ›› Issue (6): 1032-1037.DOI: 10.7517/issn.1674-0475.200409

甲状腺微小乳头状癌中央区淋巴结转移复发相关因素研究分析

谭学礼¹, 刘轼初¹, 钟晓玲¹, 刘荣彬²

1. 深圳市坪山区人民医院, 广东深圳 518118;
2. 中山大学孙逸仙纪念医院, 广东广州 510120

收稿日期:2020-04-17 出版日期:2020-11-15 发布日期:2020-11-15
通讯作者: 谭学礼
基金资助:
深圳市坪山区卫生系统科研项目（201818）资助

Risk Factors Related to Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

TAN Xueli¹, LIU Shichu¹, ZHONG Xiaoling¹, LIU Rongbin²

1. Pingshan District People's Hospital, Shenzhen 518118, Guangdong, P. R. China;
2. Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong, P. R. China

Received:2020-04-17 Online:2020-11-15 Published:2020-11-15

摘要/Abstract

摘要： 甲状腺微小乳头状癌（PTMC）发病率逐年升高，中央区淋巴结转移是影响患者生存预后的重要危险因素。本研究通过回顾性收集经病理确诊为cN0期PTMC患者（肿瘤直径≤ 10 mm）198例，分析了患者一般临床特征、超声声像图特征、细针穿刺活检（FNAC）结果、BRAFV600E突变情况及病理等资料，利用单因素和多因素Logistic回归分析对中央区淋巴结转移相关危险因素进行统计。结果发现：单因素分析提示，年龄<45岁、男性、超声提示微小钙化、肿瘤直径≥ 5 mm、TI-RADS评分≥ 8分与PTMC患者发生中央区淋巴结转移有显著关系。多因素分析发现肿瘤直径≥ 5 mm、超声提示微小钙化、TI-RADS评分≥ 8分是中央区淋巴结转移的独立危险因素。因此，瘤体直径越大、TI-RADS评分升高的cN0期PTMC患者中央区淋巴结转移风险增加。本文结果可在临床医师制定治疗策略时提供参考依据。

关键词: 甲状腺微小乳头状癌, 中央区淋巴结转移, 微小钙化, 肿瘤直径, TI-RADS评分

Abstract: The incidence of papillary thyroid microcarcinoma (PTMC) is increasing year by year. Central lymph node metastasis (CLNM) is one of the important prognostic factors for the patients of PTMC. A retrospective study was performed on 198 patients with cN0 PTMC (tumor diameter ≤ 10 mm). Basic data (e.g., gender, age, tumor location, tumor diameter) of eligible patients were extracted, as well as the pathology, ultrasound, fine-needle aspiration cytology (FNAC) results and BRAFV600E mutation analysis. The results of univariate analysis indicated that age <45 years, male, punctate echogenic foci on sonography, tumor size ≥ 5 mm, and ACR TI-RADS scores ≥ 8 were related to predict CLNM in PTMC patients. The results of multivariate analysis indicated that tumor size ≥ 5 mm, punctate echogenic foci on sonography, and ACR TI-RADS scores ≥ 8 were independent risk factors for CLNM. Moreover, larger tumor volume and higher TI-RADS scores were associated with greater risk of CLNM in cN0 PTMC patients, whom clinicians should take a more radical treatment strategy for.

Key words: papillary thyroid microcarcinoma, central lymph mode metastasis, microcalcification, tumor size, TI-RADS score

谭学礼, 刘轼初, 钟晓玲, 刘荣彬. 甲状腺微小乳头状癌中央区淋巴结转移复发相关因素研究分析[J]. 影像科学与光化学, 2020, 38(6): 1032-1037.

TAN Xueli, LIU Shichu, ZHONG Xiaoling, LIU Rongbin. Risk Factors Related to Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma[J]. Imaging Science and Photochemistry, 2020, 38(6): 1032-1037.

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甲状腺微小乳头状癌中央区淋巴结转移复发相关因素研究分析

Risk Factors Related to Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

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