影像科学与光化学 ›› 2020, Vol. 38 ›› Issue (6): 1082-1087.DOI: 10.7517/issn.1674-0475.200603

• 综述与论文 • 上一篇    下一篇

早孕期超声参数联合孕酮和β-hCG对自然流产的预测价值

范宏艳, 梁甜甜   

  1. 海淀区妇幼保健院, 北京 100089
  • 收稿日期:2020-06-01 出版日期:2020-11-15 发布日期:2020-11-15
  • 通讯作者: 范宏艳

Predictive Value of Ultrasound Parameters Combined with Progesterone and β-hCG on Spontaneous Abortion in Early Pregnancy

FAN Hongyan, LIANG Tiantian   

  1. Haidian Maternal & Child Health Hospital, Beijing 100089, P. R. China
  • Received:2020-06-01 Online:2020-11-15 Published:2020-11-15

摘要: 本研究选取了224例孕妇作为研究对象,随访至孕28周,按妊娠结局分为流产组与未流产组,比较了两组孕妇的早孕期超声参数包括胎儿心率(FHR)、顶臀长(CRL)、平均孕囊直径(MSD)、孕囊直径-顶臀长(MSD-CRL),测定了血清孕酮和β-hCG水平,分析了自然流产的影响因素、早孕期超声参数与血清孕酮和β-hCG的关联性,评价了上述指标对自然流产的预测价值。结果发现,流产组FHR低于未流产组,MSD、MSD-CRL短于未流产组,血清孕酮、β-hCG水平低于未流产组(P<0.05);流产史、妊娠前后未规律服用叶酸、孕期丈夫吸烟、早孕期FHR、MSD、MSD-CRL、孕酮、β-hCG是自然流产的重要影响因素(P<0.05);早孕期FHR、MSD、MSD-CRL与血清孕酮、β-hCG呈正相关(P<0.05);早孕期FHR、MSD、MSD-CRL与血清孕酮、β-hCG联合预测自然流产的效果优于上述指标单独检测。因此可知,早孕期超声参数FHR、MSD、MSD-CRL与孕酮、β-hCG均为自然流产的重要影响因素,联合检测具有较高预测价值。

关键词: 自然流产, 早孕期, 超声参数, 孕酮, &beta, -hCG

Abstract: 224 pregnant women were selected as the research object, followed up to 28 gestational weeks, and divided into abortion group and non-abortion group. The ultrasound parameters including fetal heart rate (FHR), crown-rump length (CRL), mean gestational sac diameter (MSD), mean sac diameter-crown-rump length (MSD-CRL) in early pregnancy of two groups were compared, as well as serum progesterone and β-hCG levels. Besides the influencing factors of spontaneous abortion, the correlation between ultrasound parameters and serum progesterone and β-hCG were analyzed too. In addition, the predictive value of the above indexes for spontaneous abortion was evaluated. The results showed that the FHR of the abortion group was lower than that of the non-abortion group, the MSD and MSD-CRL were shorter than that of the non-abortion group, and the serum progesterone and β-hCG levels were lower than that of the non-abortion group (P<0.05). The history of miscarriage, irregular intake of folic acid before and after pregnancy, husband smoking during pregnancy, FHR, MSD, MSD-CRL,progesterone, β-hCG in early pregnancy were important influencing factors for spontaneous abortion (P<0.05). FHR, MSD, MSD-CRL in early pregnancy were positively correlated with serum progesterone and β-hCG (P<0.05). The efficacy of FHR, MSD, MSD-CRL combined with serum progesterone and β-hCG on spontaneous abortion in early pregnancy was better than the above indicators alone. In conclusion, ultrasound parameters such as FHR, MSD, MSD-CRL and progesterone, β-hCG in early pregnancy are important influencing factors of spontaneous abortion, and the combined detection has good predictive value.

Key words: spontaneous abortion, early pregnancy, ultrasound parameters, progesterone, β-hCG