超声弹性成像参数联合血清MK和VEGF对分化型甲状腺癌的诊断价值及与肿瘤恶性程度关系研究

doi:10.7517/issn.1674-0475.200609

摘要/Abstract

摘要： 本研究选取了分化型甲状腺癌（DTC）患者106例为甲状腺癌组，同期106例甲状腺腺瘤患者为甲状腺腺瘤组，检测比较了两组患者的超声弹性成像参数（弹性比值、蓝色面积比值）、血清中期因子（midkine，MK）、血管内皮生长因子（VEGF）水平。研究结果发现，弹性比值、蓝色面积比值、血清MK和VEGF水平与DTC患者淋巴结转移、包膜侵犯、临床分期相关（P<0.05）；弹性比值、蓝色面积比值、血清MK和VEGF水平联合诊断DTC的曲线下面积（AUC）为0.888；弹性比值、蓝色面积比值、血清MK及VEGF水平与DTC患者组织中趋化因子受体（CXCR）4、解聚素金属蛋白酶（ADAM）9、靶向Xklp2靶蛋白（TPX2）基因表达量呈正相关，与程序性细胞死亡因子（PDCD）4基因表达量呈负相关。这些结果提示超声弹性成像参数、血清MK及VEGF水平上调可能用来评估DTC患者病情程度及肿瘤恶性程度，三者联合对DTC具有可靠诊断价值，可为临床诊治提供参考。

关键词: 超声弹性成像参数, 中期因子, 血管内皮生长因子, 分化型甲状腺癌, 肿瘤恶性程度, 受试者工作特征曲线

Abstract: In this research, 106 patients with DTC were selected as the thyroid cancer group, and 106 patients with thyroid adenoma in the same period were selected as the thyroid adenoma group. The ultrasound elastography parameters (elasticity ratio, blue area ratio), serum midkine (MK) and vascular endothelial growth factor (VEGF) levels of patients in two groups were tested and compared. The study found that the elasticity ratio, blue area ratio, serum MK, and VEGF levels were related to lymph node metastasis, capsule invasion and clinical staging in DTC patients (P<0.05). The area under the curve (AUC) for the combined diagnosis of DTC by elasticity ratio, blue area ratio, serum MK and VEGF levels is 0.888. In tissues of DTC patients, elasticity ratio, blue area ratio, serum MK and VEGF levels were positively correlated with the expression of chemokine receptor (CXCR) 4, disaggregated metalloproteinase (ADAM) 9 and targeting Xklp2 target protein (TPX2) gene, while negatively correlated with the expression of programmed cell death factor (PDCD) 4 gene. It was suggested that the up-regulation of ultrasound elastography parameters, serum MK and VEGF levels may evaluate the condition of patients with DTC and the degree of tumor malignancy. The combination of the three has a reliable diagnostic value for DTC and can provide new ideas for clinical diagnosis and treatment.

Key words: ultrasound elastography parameters, midkine, vascular endothelial growth factor, differentiated thyroid cancer, tumor malignancy, receiver operating characteristic curve

徐林霞, 王素萍, 徐国霞, 刘福娟. 超声弹性成像参数联合血清MK和VEGF对分化型甲状腺癌的诊断价值及与肿瘤恶性程度关系研究[J]. 影像科学与光化学, 2021, 39(1): 12-18.

XU Linxia, WANG Suping, XU Guoxia, LIU Fujuan. The Efficacy of Ultrasound Elastography Parameters Combined with Serum MK and VEGF in the Diagnosis of Differentiated Thyroid Cancer and the Relationship with the Malignant Degree of Tumor[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(1): 12-18.

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