螺旋CT成像联合血清copeptin、IL-18水平检测在急性脑梗死患者神经功能及预后评估中的应用价值

doi:10.7517/issn.1674-0475.200615

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (1): 34-39.DOI: 10.7517/issn.1674-0475.200615

螺旋CT成像联合血清copeptin、IL-18水平检测在急性脑梗死患者神经功能及预后评估中的应用价值

张艳锋, 张岚, 韩辉

冀中能源邢台矿业集团有限责任公司总医院内一科, 河北邢台 054000

收稿日期:2020-06-30 发布日期:2021-01-13
通讯作者: 韩辉

Application Value of Spiral CT Imaging Combined with Detection of Serum Copeptin and IL-18 Levels in Neurological Function and Prognosis Assessment of Patients with Acute Cerebral Infarction

ZHANG Yanfeng, ZHANG Lan, HAN Hui

Department of Internal Medicine, General Hospital of Jizhong Energy Xingtai Mining Group Co., Ltd., Xingtai 054000, Hebei, P. R. China

Received:2020-06-30 Published:2021-01-13

摘要/Abstract

摘要： 本文选取74例急性脑梗死（ACI）患者作为研究对象，入院时根据美国国立卫生院卒中量表（NIHSS）评分分为重度组（NIHSS评分>15分，n=21）、中度组（NIHSS评分5~15分，n=24）、轻度组（NIHSS评分<5分，n=29），均接受血清copeptin和IL-18水平检测及螺旋CT成像检查。结果发现，随ACI神经功能缺损加重，血清copeptin、白细胞介素18（IL-18）水平及峰值时间升高，CBV、CBF异常下降。经ROC曲线显示，血清IL-18联合CBF预测ACI患者预后不良的曲线下面积（AUC）最大。由上述结果可见螺旋CT成像参数、血清copeptin、IL-18水平与ACI患者神经功能存在一定相关性，三者联合为临床实现ACI患者个体化治疗和改善预后提供了可能。

关键词: 螺旋CT成像, 和肽素, 白细胞介素18, 急性脑梗死, 神经功能, 受试者工作特征曲线

Abstract: A total of 74 patients with ACI in our hospital were selected as the research objects. According to the National Institutes of Health Stroke Scale (NIHSS) score, they were divided into severe group (NIHSS score >15 points, n=21), moderate group (NIHSS score 5-15 points, n=24), and mild group (NIHSS score <5 points, n=29). All received the detection of serum copeptin, IL-18 levels and spiral CT imaging. The results showed that with the aggravation of ACI neurological deficits, serum copeptin and interleukin 18 (IL-18) levels and peak time increased, while CBV and CBF decreased abnormally. The ROC curve showed that the area under the curve (AUC) of serum IL-18 combined with CBF to predict poor prognosis of ACI patients was the largest. It can be seen that there is a certain correlation between spiral CT imaging parameters, serum copeptin, IL-18 and the neurological function of ACI patients. The combination of the three provides the possibility to achieve individualized treatment of ACI patients and improve the prognosis.

Key words: spiral CT imaging, copeptin, interleukin 18, acute cerebral infarction, neural function, receiver operating characteristic curve

张艳锋, 张岚, 韩辉. 螺旋CT成像联合血清copeptin、IL-18水平检测在急性脑梗死患者神经功能及预后评估中的应用价值[J]. 影像科学与光化学, 2021, 39(1): 34-39.

ZHANG Yanfeng, ZHANG Lan, HAN Hui. Application Value of Spiral CT Imaging Combined with Detection of Serum Copeptin and IL-18 Levels in Neurological Function and Prognosis Assessment of Patients with Acute Cerebral Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(1): 34-39.

参考文献

[1] 高峰, 迟景宏, 王欣平, 等. 急性脑梗死患者血清Caspase-3和神经元特异性烯醇化酶的表达及意义[J]. 中国老年学杂志, 2018, 38(1):73-75.
[2] 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9):666-682.
[3] Harris D, Hall C, Lobay K, et al. Canadian association of emergency physicians position statement on acute ischemic stroke[J]. Canadian Journal of Emergency Medicine, 2015, 17(2):217-226.
[4] Zhang Y Z, Wang J, Xu F. Circulating miR-29b and miR-424 as prognostic markers in patients with acute cerebral infarction[J]. Clinical Laboratory, 2017, 63(10):1667-1674.
[5] Chen L, Yang Q, Ding R, et al. Carotid thickness and atherosclerotic plaque stability, serum inflammation, serum MMP-2 and MMP-9 were associated with acute cerebral infarction[J]. Experimental and Therapeutic Medicine, 2018, 16(6):5253-5257.
[6] Demaerschalk B M, Kleindorfer D O, Adeoye O M, et al. Scientific rationale for the inclusion and exclusion criteria for intravenous alteplase in acute ischemic stroke[J]. Stroke, 2016, 47(2):581-641.
[7] 刘志文, 蒋云, 王蕊, 等. 多参数半定量Alberta卒中项目早期CT评分联合评价在急性缺血性卒中的应用[J]. 中华医学杂志, 2018, 98(21):1697-1702.
[8] 刘东清, 赵建华, 张龙, 等. 脑梗死后磁共振灌注加权成像-弥散加权成像CBF-DWI不匹配的临床意义和动态变化[J]. 中风与神经疾病杂志, 2018, 35(9):791-795.
[9] 柯伟, 邓小容, 李文澜, 等. 急性缺血性脑梗死动脉再通后24 h ASPECTS的变化对患者预后的预测价值[J]. 中国老年学杂志, 2018, 38(11):2573-2575.
[10] 赵启媛, 金平, 陈生, 等. CT灌注成像在急性缺血性脑血管病中的诊断价值[J]. 安徽医学, 2018, 39(7):841-844.
[11] 甘中亮, 吴耀贤, 余海波. 64层螺旋CT脑灌注成像在急性脑梗死诊断中的应用[J]. 中国实用神经疾病杂志, 2017, 20(11):68-70.
[12] Lu W J, Zeng L L, Wang Y, et al. Blood microRNA-15a Correlates with IL-6, IGF-1 and acute cerebral ischemia[J]. Current Neurovascular Research, 2018, 15(1):63-71.
[13] 陈声妹, 李其富, 王淑荣, 等. 海南籍黎族和汉族急性脑梗死患者C反应蛋白和白细胞介素18的基因多态性研究[J]. 中华老年心脑血管病杂志, 2019, 21(1):47-50.
[14] 庄源, 魏广宽. 血清copeptin在急性脑梗死患者病情评估中的应用[J]. 中国卫生标准管理, 2018, 9(13):60-62.
[15] 郑晓东, 张介立, 易飞. 血浆和肽素与高敏C反应蛋白在脑梗死病情评估中的应用[J]. 广东医学, 2017, 38(23):3631-3632.

螺旋CT成像联合血清copeptin、IL-18水平检测在急性脑梗死患者神经功能及预后评估中的应用价值

Application Value of Spiral CT Imaging Combined with Detection of Serum Copeptin and IL-18 Levels in Neurological Function and Prognosis Assessment of Patients with Acute Cerebral Infarction

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 4

编辑推荐

Metrics

本文评价

[1]	徐林霞, 王素萍, 徐国霞, 刘福娟. 超声弹性成像参数联合血清MK和VEGF对分化型甲状腺癌的诊断价值及与肿瘤恶性程度关系研究[J]. 影像科学与光化学, 2021, 39(1): 12-18.
[2]	韦菊临, 赵志雄. 青年与中老年急性脑梗死MR特点和危险因素对比研究[J]. 影像科学与光化学, 2020, 38(4): 684-689.
[3]	郭小云, 王金桃. 急性脑梗死患者心电图特征与病情分型及其预后状况的关系[J]. 影像科学与光化学, 2020, 38(2): 286-290.
[4]	龚玉萍, 王洋. 实时超声心动图与平板运动心电图诊断冠心病的ROC曲线分析[J]. 影像科学与光化学, 2019, 37(6): 598-603.