脑胶质瘤磁共振弥散张量成像定量参数与VEGF、MMP-9表达的相关性

doi:10.7517/issn.1674-0475.200703

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (1): 115-119.DOI: 10.7517/issn.1674-0475.200703

脑胶质瘤磁共振弥散张量成像定量参数与VEGF、MMP-9表达的相关性

吴静¹, 沈慧聪²

1. 北京怀柔医院影像科, 北京 101400;
2. 首都医科大学附属北京天坛医院放射科, 北京 100050

收稿日期:2020-07-10 发布日期:2021-01-13
通讯作者: 吴静

Correlation Between the Quantitative Parameters of MR Diffusion Tensor Imaging and the Expression of VEGF and MMP-9 in Brain Gliomas

WU Jing¹, SHEN Huicong²

1. Department of Imaging, Beijing Huairou Hospital, Beijing 101400, P. R. China;
2. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P. R. China

Received:2020-07-10 Published:2021-01-13

摘要/Abstract

摘要： 本研究旨在分析脑胶质瘤患者的磁共振弥散张量成像（DTI）参数与病变组织血管内皮生长因子（VEGF）和基质金属蛋白酶-9（MMP-9）表达的相关性，以及DTI参数对脑胶质瘤进行分级诊断的价值。根据病理分级将102例脑胶质瘤患者分为低级别组（47例）和高级别组（55例），均行MRI和DTI检查，定量测定表观弥散系数（ADC）、各向异性分数（FA）、相对ADC（rADC）、相对FA（rFA）值及相对轴向扩散系数（rAD）值；用免疫组化法检测VEGF和MMP-9表达情况。结果显示，高级别组患者的rADC、ADC、rAD、FA、rFA均低于低级别组（P<0.05）；高级别组患者的VEGF和MMP-9阳性表达均高于低级别组（P<0.05）。rADC、ADC、rAD、FA、rFA与VEGF和MMP-9表达均呈负相关（P<0.05）；rADC、ADC、rAD、FA、rFA对脑胶质瘤分级诊断的AUC均具有一定诊断价值（P<0.05）。本研究结果提示DTI定量参数与脑胶质瘤VEGF和MMP-9表达具有相关性，且有助于脑胶质瘤的分级诊断。

关键词: 脑胶质瘤, 磁共振弥散张量成像, 血管内皮生长因子, 基质金属蛋白酶-9, 病理分级

Abstract: The correlation between the quantitative parameters of magnetic resonance diffusion tensor imaging (DTI) and the expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) was analyzed in this study, as well as the diagnostic value of the parameters on pathological grade in brain gliomas. According to the pathological grade, 102 patients with brain gliomas were divided into low-grade group (47 cases) and high-grade group (55 cases). All patients were examined by MRI and DTI, through which the ADC, FA, rADC, rFA and rAD were measured. The expression of VEGF and MMP-9 were detected by immunohistochemistry. The results show that, the rADC, ADC, rAD, FA and rFA in high-grade group were lower than those of low-grade group (P<0.05). The positive expression of VEGF and MMP-9 in high-grade group were higher than those of low-grade group (P<0.05). The rADC, ADC, rAD, FA and rFA were negatively correlated with VEGF and MMP-9 expression (P<0.05). The AUC of rADC, ADC, rAD, FA and rFA in diagnosing the grade of brain glioma had a certain value (P<0.05). In conclusion, the quantitative parameters of DTI were correlated with the expression of VEGF and MMP-9 in brain gliomas, which was helpful to diagnose the grade of brain glioma.

Key words: brain gliomas, MR diffusion tensor imaging, vascular endothelial growth factor, matrix metalloproteinase-9, pathological grade

吴静, 沈慧聪. 脑胶质瘤磁共振弥散张量成像定量参数与VEGF、MMP-9表达的相关性[J]. 影像科学与光化学, 2021, 39(1): 115-119.

WU Jing, SHEN Huicong. Correlation Between the Quantitative Parameters of MR Diffusion Tensor Imaging and the Expression of VEGF and MMP-9 in Brain Gliomas[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(1): 115-119.

参考文献

[1] Holly K S, Fitz-Gerald J S, Barker B J, et al. Differentiation of high-grade glioma and intracranial metastasis using volumetric diffusion tensor imaging tractography[J]. World Neurosurgery, 2018, 120(1):131-141.
[2] 马庆防, 黎军, 王永楠, 等. COX-2与MMP-9和VEGF在胶质瘤中的表达及意义[J]. 中华肿瘤防治杂志, 2016, 23(S2):24-25.
[3] Li Y, Zhang W. Quantitative evaluation of diffusion tensor imaging for clinical management of glioma[J]. Neurosurgical Review, 2018, 43(3):881-891.
[4] 孙功能, 朱虎, 邱伟, 等. 磁共振弥散张量成像定量参数在胶质瘤分级诊断中的应用研究[J]. 医学影像学杂志, 2019, 29(4):14-17.
[5] 国家卫生健康委员会医政医管局. 脑胶质瘤诊疗规范(2018年版)[J]. 中华神经外科杂志, 2019, 35(3):217-239.
[6] 张涛, 王辉,杨晓文. 脑胶质瘤中Id1与VEGF的表达及其与肿瘤血管生成的关系[J]. 解剖学研究, 2018, 40(5):24-27.
[7] 李论, 戴金龙, 胡硕, 等. 磁共振弥散张量成像在脑胶质瘤诊断中应用价值研究[J]. 创伤与急危重病医学, 2018, 6(6):422.
[8] 蔡志超, 池琦. 磁共振扩散张量成像定量参数对脑胶质瘤分级的诊断价值[J]. 现代肿瘤医学, 2019, 27(11):2005-2009.
[9] 徐慧琳, 蔡元卿, 龚明福, 等. DTI定量参数对脑胶质瘤的诊断价值及其与血管内皮生长因子、细胞核增殖相关抗原的关系[J]. 现代生物医学进展, 2018, 18(14):71-74.
[10] Suh C H, Kim H S, Jung S C, et al. Diffusion-weighted imaging and diffusion tensor imaging for differentiating high-grade glioma from solitary brain metastasis:a systematic review and meta-analysis[J]. American Journal of Neurora-diology, 2018, 39(7):1208.
[11] 侯宗刚, 蔡旭, 谢坚, 等. 应用弥散张量成像技术判定高级别胶质瘤侵袭范围的初步研究[J]. 中华神经外科杂志, 2018, 34(4):344-348.
[12] 李章宇, 钱海峰, 孙胜杰, 等. 磁共振灌注加权成像与扩散张量成像在脑胶质瘤分级诊断中的应用[J]. 中华全科医学, 2017, 15(6):1013-1015.
[13] Sridhar K, Srinivasan K. Diffusion tensor imaging and tractography in diffuse intrinsic pontine glioma:a major determinant of resectability and description of a new subtype[J]. Neurology India, 2019, 67(1):292-297.
[14] 唐玉蓉, 成立峰, 于本章. miR-122和VEGF在胶质瘤患者中表达的临床意义[J]. 中国免疫学杂志, 2019, 35(7):87-90.
[15] 吴建珩, 李晓辉, 单峤, 等. 星形胶质细胞上调基因1和基质金属蛋白酶9在人脑胶质瘤中的表达及其相关性研究[J]. 中国全科医学, 2014, 17(6):648-651.
[16] 王佳, 封华, 梁奕, 等. DTI相关参数对脑胶质瘤的诊断价值及与VEGF、MMP-9、uPA表达的相关性[J]. 放射学实践, 2017, 32(9):932-935.

脑胶质瘤磁共振弥散张量成像定量参数与VEGF、MMP-9表达的相关性

Correlation Between the Quantitative Parameters of MR Diffusion Tensor Imaging and the Expression of VEGF and MMP-9 in Brain Gliomas

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