虚拟导航超声支气管镜灌洗液miRNA在不同大体分型肺癌患者体内表达差异及诊断周围型肺癌的效能研究

doi:10.7517/issn.1674-0475.200817

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (2): 273-279.DOI: 10.7517/issn.1674-0475.200817

虚拟导航超声支气管镜灌洗液miRNA在不同大体分型肺癌患者体内表达差异及诊断周围型肺癌的效能研究

颜晶晶¹, 蔡青波², 郭峰睿¹, 刘颖¹, 张业¹

1. 河北中石油中心医院, 河北廊坊 065000;
2. 廊坊市人民医院, 河北廊坊 065000

收稿日期:2020-08-28 出版日期:2021-03-15 发布日期:2021-03-12
通讯作者: 张业
基金资助:
河北省廊坊市科学技术研究与发展计划自筹经费项目（2017013046）资助

Study on the Difference of MicroRNA Expression in Lavage Fluid of Virtual Navigation Ultrasound Bronchoscopy in Patients with Different Types of Lung Cancer and the Diagnostic Efficacy in Peripheral Lung Cancer

YAN Jingjing¹, CAI Qingbo², GUO Fengrui¹, LIU Ying¹, ZHANG Ye¹

1. Hebei Petrochina Central Hospital, Langfang 065000, Hebei, P. R. China;
2. Langfang People's Hospital, Langfang 065000, Hebei, P. R. China

Received:2020-08-28 Online:2021-03-15 Published:2021-03-12

摘要/Abstract

摘要： 本文探讨了虚拟导航超声支气管镜灌洗液微小RNA （miRNA）在不同大体分型肺癌患者体内的表达差异及诊断周围型肺癌（PLC）的效能。选取65例中心型肺癌（CLC）患者（中心型组）及65例PLC患者（周围型组），均检测miR-1260b、miR-135a-3p、miR-299-3p、miR-3175及癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）表达。周围型组miR-1260b低于中心型组，miR-135a-3p、miR-3175高于中心型组（P<0.05）；miR-1260b、miR-135a-3p、miR-3175与CEA、NSE相关，且与PLC显著相关（P<0.05）；miR-1260b、miR-135a-3p联合诊断PLC的AUC高于单独诊断；miR-1260b、miR-135a-3p、miR-299-3p、miR-3175联合诊断PLC转移的效能高于单独诊断。故可知PLC和CLC患者虚拟导航超声支气管镜灌洗液中miR-1260b、miR-135a-3p、miR-3175表达存在差异，联合检测对PLC具有重要诊断价值。而且miR-1260b、miR-135a-3p、miR-299-3p、miR-3175联合检测可预测PLC转移，为临床诊治提供依据。

关键词: 虚拟支气管镜导航, 支气管超声导向鞘, 周围型肺癌, 中心型肺癌, 灌洗液, 微小RNA

Abstract: This study aimed to investigate the differences in the expression of microRNA (miRNA) in lavage fluid of virtual navigation ultrasound bronchoscopy in patients with different types of lung cancer and the diagnostic efficacy in peripheral lung cancer (PLC). There were 65 patients with central lung cancer (CLC) (central group) and 65 patients with PLC (peripheral group) who were selected. The expressions of miR-1260b, miR-135a-3p, miR-299-3p, miR-3175 in lavage fluid were detected, as well as the expression of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE). The miR-1260b of the peripheral group was lower than that of the central group, and the miR-135a-3p and miR-3175 were higher than that of the central group (P<0.05). miR-1260b, miR-135a-3p, miR-3175 were related to CEA and NSE, and significantly related to PLC (P<0.05). The AUC of miR-1260b and miR-135a-3p combined diagnosis of PLC was higher than that of single diagnosis. The combined diagnosis efficiency of miR-1260b, miR-135a-3p, miR-299-3p, and miR-3175 was higher than any single one. Therefore, it can be seen that miR-1260b, miR-135a-3p, and miR-3175 in the lavage fluid of virtual navigation ultrasound bronchoscope for PLC and CLC patients are differentially expressed. Combined detection is of great value for the diagnosis of PLC. In addition, the combined detection of miR-1260b, miR-135a-3p, miR-299-3p, and miR-3175 can predict PLC metastasis and provide a basis for clinical diagnosis and treatment.

Key words: virtual bronchoscopy navigation, bronchial ultrasound guide sheath, peripheral lung cancer, central lung cancer, lavage fluid, microRNA

颜晶晶, 蔡青波, 郭峰睿, 刘颖, 张业. 虚拟导航超声支气管镜灌洗液miRNA在不同大体分型肺癌患者体内表达差异及诊断周围型肺癌的效能研究[J]. 影像科学与光化学, 2021, 39(2): 273-279.

YAN Jingjing, CAI Qingbo, GUO Fengrui, LIU Ying, ZHANG Ye. Study on the Difference of MicroRNA Expression in Lavage Fluid of Virtual Navigation Ultrasound Bronchoscopy in Patients with Different Types of Lung Cancer and the Diagnostic Efficacy in Peripheral Lung Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(2): 273-279.

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虚拟导航超声支气管镜灌洗液miRNA在不同大体分型肺癌患者体内表达差异及诊断周围型肺癌的效能研究

Study on the Difference of MicroRNA Expression in Lavage Fluid of Virtual Navigation Ultrasound Bronchoscopy in Patients with Different Types of Lung Cancer and the Diagnostic Efficacy in Peripheral Lung Cancer

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