影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (2): 246-250.DOI: 10.7517/issn.1674-0475.200908

• 综述与论文 • 上一篇    下一篇

颈动脉超声联合CT和血清miR-124、miR-155对颈动脉狭窄患者继发性脑梗的风险预测价值

王适达, 王海虹, 张立娜   

  1. 保定市第二中心医院, 河北 保定 072750
  • 收稿日期:2020-09-21 出版日期:2021-03-15 发布日期:2021-03-12
  • 通讯作者: 王海虹

Value of Carotid Ultrasound Combined with CT and Serum miR-124 and miR-155 in Predicting the Risk of Secondary Cerebral Infarction in Patients with Carotid Stenosis

WANG Shida, WANG Haihong, ZHANG Lina   

  1. Baoding No. 2 Central Hospital, Baoding 072750, Hebei, P. R. China
  • Received:2020-09-21 Online:2021-03-15 Published:2021-03-12

摘要: 本文探讨了颈动脉超声检查联合CT和血清微小RNA-124(miR-124)、微小RNA-155(miR-155)对颈动脉狭窄患者继发性脑梗的风险预测价值。以43例颈动脉狭窄患者为颈动脉狭窄组,正常志愿者43例为正常组,用RT-PCR法检测miR-124、miR-155表达,采用颈动脉超声检查颈动脉狭窄,采用CT检查颈部血管。结果显示,与正常组相比,颈动脉狭窄组miR-124、miR-155表达升高(P<0.05)。与超声、CT检查相比,超声检查联合CT检查颈动脉狭窄准确率、诊断价值较高(P<0.05)。本研究认为,颈动脉超声、CT、miR-124、miR-155对颈动脉狭窄的诊断价值较高,且可用于预测继发性脑梗的风险,预测价值较为理想。

关键词: 颈动脉超声检查, CT, miR-124, miR-155, 颈动脉狭窄, 继发性脑梗

Abstract: This study explored the value of carotid ultrasound combined with CT and serum microRNA-124 (miR-124) and microRNA-155 (miR-155) in predicting the risk of secondary cerebral infarction in patients with carotid stenosis.Forty-three patients with carotid stenosis were selected as carotid stenosis group, and 43 normal volunteers were selected as normal group. The expression of miR-124 and miR-155 was detected by RT-PCR. Carotid artery stenosis was examined by carotid ultrasound. The blood vessels in the neck were examined by CT. The results showed that compared with the normal group, the expression of miR-124 and miR-155 in carotid stenosis group was increased (P<0.05).Compared with ultrasound and CT, ultrasound combined with CT had higher accuracy and diagnostic value (P<0.05).It is found that carotid ultrasound, CT, miR-124 and miR-155 have high diagnostic value for carotid artery stenosis, and can be used to predict the risk of secondary cerebral infarction.

Key words: carotid ultrasound, CT, miR-124, miR-155, carotid artery stenosis, secondary cerebral infarction