影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (3): 396-400.DOI: 10.7517/issn.1674-0475.200913

• 综述与论文 • 上一篇    下一篇

超声心动图参数对新活素治疗急性心梗患者PCI术后左心室重构及改善收缩功能的作用评估

张樊, 金希华, 汪蛟龙   

  1. 淮南东方医院集团总院, 安徽 淮南 232001
  • 收稿日期:2020-09-25 出版日期:2021-05-15 发布日期:2021-05-17
  • 通讯作者: 汪蛟龙

Evaluation of Echocardiographic Parameters on Left Ventricular Remodeling and Systolic Function of Patients with Acute Myocardial Infarction after PCI: the Role of rhBNP

ZHANG Fan, JIN Xihua, WANG Jiaolong   

  1. General Hospital of Huainan Oriental Hospital Group, Huainan 232001, Anhui, P. R. China
  • Received:2020-09-25 Online:2021-05-15 Published:2021-05-17

摘要: 本研究选取了108例经皮冠脉介入手术(PCI)治疗的急性心肌梗死(AMI)患者,以超声心动图为工具,探讨了新活素治疗对左心室重构及收缩功能的影响。采用随机数字表将研究对象分为研究组和对照组,每组各54例,两组患者术后均给予抗凝、抗血小板、降血脂等基础治疗,研究组患者同时给予新活素治疗。治疗后,研究组的FMD、NO、LVEF高于对照组(P<0.05),GLS、GAS、ET-1水平低于对照组(P<0.05)。在PCI术后1年,研究组的主要不良心血管事件(MACE)发生率为9.26%,低于对照组的24.07%(P<0.05)。本研究证实,新活素对于经PCI手术的AMI患者,具有改善血管内皮功能、左室收缩功能及左心室心肌应变能力的作用,有利于降低患者MACE的发生率。

关键词: 新活素, 急性心肌梗死, 经皮冠脉介入手术, 左心室重构, 收缩功能

Abstract: The aim of this study was to investigate the effect of lyophilized recombinant human brain natriuretic peptide (rhBNP) on left ventricular remodeling and systolic function in patients with acute myocardial infarction (AMI) who treated with percutaneous coronary intervention (PCI). There were 108 patients with AMI treated by PCI who were selected and randomly divided into study group and control group, with 54 cases in each group. Patients in both groups were given basic treatment such as anticoagulation, antiplatelet and lipid-lowering after operation, and patients in the study group were also given rhBNP treatment. After treatment, FMD, NO, LVEF in the study group were higher than those in the control group (P<0.05), while GLS, GAS, and ET-1 levels were lower than those in the control group (P<0.05). One year after PCI, the incidence of major adverse cardiovascular events (MACE) in the study group was 9.26%, which was lower than 24.07% in the control group (P<0.05). The treatment of rhBNP on AMI patients with PCI has improved vascular endothelial function, left ventricular systolic function and left ventricular myocardial strain, which is beneficial to reduce the incidence of MACE.

Key words: lyophilized recombinant human brain natriuretic peptide, acute myocardial infarction, percutaneous coronary intervention, left ventricular remodeling, systolic function