关键词: 多层螺旋CT灌注成像, 基质金属蛋白酶-9, 急性脑缺血

Abstract: In this paper, a total of 122 patients with acute cerebral ischemia were selected for intervention. Multi-slice spiral CT perfusion (MSCTP) was performed before and after the intervention. The levels of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1) in serum were also detected. At 7 days after the intervention, it was found that the relative cerebral blood flow (rCBF) of the ischemic marginal zone and the ischemic central zone were higher than those before the intervention. The relative mean transit time (rMTT) was shorter than those before the intervention, and the serum MMP-9 and TIMP-1 were also lower than before. The AUC of rCBF in ischemic marginal zone and ischemic central zone combined with MMP-9 for predicting the poor prognosis of acute cerebral ischemia after 7 days of intervention was 0.933. In a word, it can be seen that the rCBF in the ischemic marginal zone and central ischemic zone increased, the rMTT shortened, and the serum MMP-9 and TIMP-1 levels decreased in patients with acute cerebral ischemia 7 days after intervention. And there is a certain value of the combined prediction for evaluating the prognosis of patients with acute cerebral ischemia.

Key words: multi-slice spiral CT perfusion, matrix metalloproteinase-9, acute cerebral ischemia