功能磁共振成像技术在药物难治性颞叶癫痫患者的记忆、语言及认知功能评估方面的应用

doi:10.7517/issn.1674-0475.201011

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (3): 417-421.DOI: 10.7517/issn.1674-0475.201011

功能磁共振成像技术在药物难治性颞叶癫痫患者的记忆、语言及认知功能评估方面的应用

赵腾跃¹, 李华², 殷涛¹, 刘东旭¹, 魏浩然³

1. 保定市脑血管病医院神经内科, 河北保定 071000;
2. 河北大学附属医院内科, 河北保定 071000;
3. 保定市脑血管病医院影像科, 河北保定 071000

收稿日期:2020-10-21 出版日期:2021-05-15 发布日期:2021-05-17
通讯作者: 李华
基金资助:
河北省医学科学研究重点课题计划（20181256）资助

Application of Functional MRI in the Evaluation of Memory, Language and Cognitive Functions in Patients with Drug-refractory Temporal Lobe Epilepsy

ZHAO Tengyue¹, LI Hua², YIN Tao¹, LIU Dongxu¹, WEI Haoyan³

1. Department of Neurology, Baoding Cerebrovascular Disease Hospital, Baoding 071000, Hebei, P. R. China;
2. Department of Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, P. R. China;
3. Imaging Department, Baoding Cerebrovascular Disease Hospital, Baoding 071000, Hebei, P. R. China

Received:2020-10-21 Online:2021-05-15 Published:2021-05-17

摘要/Abstract

摘要： 本研究探究了功能磁共振成像技术评估药物难治性颞叶癫痫患者的记忆、语言及认知功能的应用价值。选取148例药物难治性颞叶癫痫患者作为实验组，另选取148例健康者作为对照组参与测试，两组患者均行功能磁共振成像技术检查记忆、语言及认知功能，分析功能磁共振成像技术的评估效果。结果表明，动词生成语言任务模式下，功能磁共振成像结果显示实验组在左侧额下回、左侧额中回、右侧中央前回、左侧颞中回、左侧颞下回和楔前叶部位激活强度明显弱于对照组。2-back目标记忆任务模式下，实验组的双侧丘脑、内侧前额叶和顶叶部位实验组的激活强度明显弱于对照组。注意力任务模式下，实验组的后扣带回、楔前叶和双侧顶叶部位激活强度明显弱于对照组（P<0.05）。综上所述，功能磁共振成像结果可以用于分析药物难治性颞叶癫痫患者的语言、记忆及认知功能，在癫痫患者的认知功能损害评估和治疗方案制定方面有重要的临床价值。

关键词: 功能磁共振成像, 颞叶癫痫, 认知功能

Abstract: The purpose of this paper was to explore the value of functional magnetic resonance imaging (fMRI) in evaluating memory, language and cognitive functions in patients with drug-resistant temporal lobe epilepsy. There were 148 patients with drug-resistant temporal lobe epilepsy who were selected as experimental group, and 148 healthy people who were selected as the control group. Both groups of patients underwent fMRI to check their memory, language and cognitive functions. And the advantages and disadvantages of fMRI were analyzed. The results showed that in the verb generation language task mode, the activation intensity in the following regions of the experimental group was significantly weaker than that of the control group, 417including the left inferior frontal gyrus, left middle frontal gyrus, right central anterior gyrus, left middle temporal gyrus, left Inferior temporal gyrus and precuneus regions. The activation intensity in the following regions of the experimental group in the 2-back target memory task mode was significantly weaker than that of the control group, including bilateral thalamus and medial prefrontal lobe, as well as parietal lobe areas. The activation intensity in the following regions of the experimental group under the attention task mode was significantly weaker than that of the control group, including the posterior cingulate gyrus and precuneus, as well as bilateral parietal lobe regions (P<0.05). In summary, the results of fMRI can be used to analyze the language, memory and cognitive functions of patients with medication-resistant temporal lobe epilepsy.

Key words: functional magnetic resonance imaging(fMRI), temporal lobe epilepsy, cognitive function

赵腾跃, 李华, 殷涛, 刘东旭, 魏浩然. 功能磁共振成像技术在药物难治性颞叶癫痫患者的记忆、语言及认知功能评估方面的应用[J]. 影像科学与光化学, 2021, 39(3): 417-421.

ZHAO Tengyue, LI Hua, YIN Tao, LIU Dongxu, WEI Haoyan. Application of Functional MRI in the Evaluation of Memory, Language and Cognitive Functions in Patients with Drug-refractory Temporal Lobe Epilepsy[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(3): 417-421.

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功能磁共振成像技术在药物难治性颞叶癫痫患者的记忆、语言及认知功能评估方面的应用

Application of Functional MRI in the Evaluation of Memory, Language and Cognitive Functions in Patients with Drug-refractory Temporal Lobe Epilepsy

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