影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (3): 407-411.DOI: 10.7517/issn.1674-0475.201015

• 综述与论文 • 上一篇    下一篇

IVIM-DWI参数对卵巢良/恶性肿瘤的诊断效能及与肿瘤标志物、临床病理因素相关性分析

林栋1, 黄家杰1, 吴尚文2, 覃尼1, 许华莉1   

  1. 1. 防城港市中医医院影像科, 广西 防城港 538021;
    2. 防城港市中医医院检验科, 广西 防城港 538021
  • 收稿日期:2020-10-30 出版日期:2021-05-15 发布日期:2021-05-17
  • 通讯作者: 林栋

The Diagnostic Efficiency of IVIM-DWI in Benign and Malignant Ovarian Tumors and the Correlation with Tumor Markers and Clinicopathological Factors

LIN Dong1, HUANG Jiajie1, WU Shangwen2, QIN Ni1, XU Huali1   

  1. 1. Department of Imaging, Fangchenggang Hospital of Traditional Chinese Medicine, Fangchenggang 538021, Guangxi, P. R. China;
    2. Department of Laboratory Medicine, Fangchenggang Hospital of Traditional Chinese Medicine, Fangchenggang 538021, Guangxi, P. R. China
  • Received:2020-10-30 Online:2021-05-15 Published:2021-05-17

摘要: 本文探讨了磁共振体素不相干运动扩散加权成像(IVIM-DWI)参数鉴别诊断卵巢良/恶性肿瘤的价值。选取卵巢肿瘤患者108例,比较良/恶性肿瘤表观扩散系数(ADC)、慢扩散系数(Dslow)等参数。结果显示,恶性肿瘤的IVIM-DWI参数(ADC值、Dslow和快扩散系数分数f值)低于良性肿瘤(P<0.05);ADC值、Dslowf值诊断恶性卵巢肿瘤的ROC曲线下面积分别为0.816、0.915和0.852(P<0.05);ADC值、Dslow与糖类抗原125(CA125)呈负相关(r=-0.457和-0.553,P<0.05);临床分期Ⅲ~Ⅳ患者的IVIM-DWI参数ADC值明显低于Ⅰ~Ⅱ患者(P<0.05)。本文结果证明IVIM-DWI技术参数在卵巢肿瘤鉴别诊断中有一定应用价值,其参数ADC、Dslow水平与恶性肿瘤患者CA125水平有关,ADC值与临床分期有关。

关键词: 磁共振体素不相干运动扩散加权成像, 卵巢肿瘤, 糖类抗原125, 临床病理

Abstract: The aim of this study was to investigate the value of introvoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI) in the diagnosis of benign and malignant ovarian tumor. There were 108 patients with ovarian tumors who were selected to compare the differences of IVMI-DWI parameters between benign and malignant tumors. The results showed that the IVIM-DWI parameters including apparent diffusion coefficient (ADC), slow diffusion coefficient (Dslow) and fast diffusion coefficient score (f value) of malignant tumor were lower than that of benign tumor (P<0.05). The area under ROC curve of ADC, Dslow and f value in the diagnosis of malignant ovarian tumor were 0.816, 0.915 and 0.852, respectively (P<0.05). ADC and Dslow were negatively correlated with carbohydrate antigen 125(CA125) (r=-0.457 and -0.553, P<0.05). The ADC in patients with clinical stage Ⅲ-Ⅳ was significantly lower than that of patients Ⅰ-Ⅱ (P<0.05). In a word, IVIM-DWI parameters have a certain application value in the diagnosis of benign and malignant ovarian tumors, and the ADC, Dslow levels are correlated with CA125 and clinical stage of patients with malignant tumors.407

Key words: introvoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI), ovarian tumor, carbohydrate antigen 125, clinicopathology