关键词: 不明原因复发性自然流产, 早孕, 超声多模态评分, 血流参数, 预测价值

Abstract: The purpose of this study was to investigate the changes of ultrasound multimodal scores and blood flow parameters in patients with unexplained recurrent spontaneous abortion and their combined predictive value.86 cases of early pregnancy patients with unexplained recurrent spontaneous abortion (URSA) were selected. According to whether miscarriage occurred within 12 weeks of gestation, they were divided into non-abortion group (62 cases) and miscarriage group (24 cases). And 86 pregnant women with normal early pregnancy during the same period were selected as the control group. Endometrial ultrasound multimodal score was detected, as well as uterine artery blood flow parameters including pulsatility index (PI), resistance index (RI), peak systolic velocity end diastolic velocity (S/D). It was found that ultrasound multimodal scores, PI, RI, S/D were significantly related to β-HCG, progesterone and miscarriage in early pregnancy patients of URSA. The AUC for combined predicting 538miscarriage in early pregnancy patients of URSA was 0.886, the 95%CI was 0.806 to 0.965. The sensitivity was 83.33%, and the specificity was 83.87%, which was better than the individual prediction of each index. It can be seen that ultrasound multimodal scores and blood flow parameters are abnormal in URSA patients. And the combined prediction for miscarriage has a good value, which can provide effective information for early clinical intervention.

Key words: unexplained recurrent spontaneous abortion, early pregnancy, ultrasound multimodal score, blood flow parameters, predictive value