定量动态增强MRI与脑胶质瘤患者血清IL-10、IL-12表达的相关性分析

doi:10.7517/issn.1674-0475.201212

摘要/Abstract

摘要： 探讨定量动态增强磁共振成像（DCE-MRI）与脑胶质瘤患者血清白细胞介素-10（IL-10）、白细胞介素-12（IL-12）表达的相关性。本研究选取脑胶质瘤患者150例作为观察组，其中低级别脑胶质瘤68例、高级别脑胶质瘤82例，并选取100例健康者作为对照组。检测两组血清IL-10和IL-12水平，观察组给予MRI动态对比增强扫描。结果显示，观察组血清IL-10、IL-12明显高于对照组（P<0.05）；观察组高级别脑胶质瘤患者容积转运常数（K^trans）、速率常数（K_e）、血管外细胞外容积分数（V_e）明显高于低级别脑胶质瘤患者（P<0.05）；高级别脑胶质瘤患者血清IL-10、IL-12明显高于低级别脑胶质瘤患者（P<0.05）；K^trans与IL-10、IL-12呈正相关（P<0.05）；K^trans、K_e、V_e联合IL-10和IL-12鉴别脑胶质瘤高级别的ROC曲线下面积为0.954，明显高于其他指标单独诊断（P<0.05）。脑胶质瘤患者MRI参数K^trans与血清IL-10、IL-12呈正相关，且在鉴别低级别和高级别脑胶质瘤中有一定应用价值。

关键词: 磁共振成像, 脑胶质瘤, 白细胞介素-10, 白细胞介素-12

Abstract: The purpose of this study was to investigate the correlation between quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and the expression of serum interleukin-10 (IL-10) and interleukin-12 (IL-12) in patients with glioma. In this study, 150 patients with glioma were included as the observation group, including 68 cases of low-grade glioma and 82 cases of high-grade glioma, as well as 100 healthy patients as control group. The serum IL-10 and IL-12 levels of the two groups were detected, and the observation group was given MRI dynamic contrast enhancement scan. Serum IL-10 and IL-12 in the observation group were significantly higher than those in the control group (P<0.05). In the observation group, the volume transport constant (K^trans), rate constant (K_e) and extracellular volume fraction (V_e) of high-grade glioma patients were significantly higher than those of low-grade glioma patients (P<0.05). The serum IL-10 and IL-12 levels of patients with high-grade glioma in the observation group were significantly higher than those of patients with low-grade glioma (P<0.05). K^trans was positively correlated with IL-10 and IL-12 (P<0.05). The area under the high grade ROC curve of K^trans, K_e, V_e combined with 579 IL-10 and IL-12 glioma was 0.954, which was significantly higher than that of other indexes (P<0.05). MRI parameter K^trans is positively correlated with serum IL-10 and IL-12 in patients with glioma, and has certain application value in differentiating low-grade and high-grade gliomas.

Key words: magnetic resonance imaging, brain glioma, interleukin-10, interleukin-12

刘铁芳, 臧晓, 张德康, 胡坚兴, 李萌, 王永昊. 定量动态增强MRI与脑胶质瘤患者血清IL-10、IL-12表达的相关性分析[J]. 影像科学与光化学, 2021, 39(4): 579-583.

LIU Tiefang, ZANG Xiao, ZHANG Dekang, HU Jianxing, LI Meng, WANG Yonghao. Correlation Analysis of Quantitative Dynamic Contrast-Enhanced MRI and Serum IL-10, IL-12 Expression in Patients with Glioma[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(4): 579-583.

参考文献

[1] 贾中正, 蒋佳珅, 沈丹丹, 等. 动态对比增强磁共振成像在脑胶质瘤患者瘤细胞增殖定量评估中的应用[J]. 山东医药, 2018,58(39):17-20.
[2] Liu C, Chen J, Zhu Y, et al. Highly sensitive MoS₂-indocyanine green hybrid for photoacoustic imaging of orthotopic brain glioma at deep site[J]. Nano-Micro Letters, 2018,10(3):48.
[3] Wu C, Cai R, Zhao T, et al. Hyaluronic acid-functionalized gadolinium oxide nanoparticles for magnetic resonance imaging-guided radiotherapy of tumors[J]. Nanoscale Research Letters, 2020,15(1):23-29.
[4] Wang H F, Chen R, He B M, et al. Initial experience with a novel method for cognitive transperineal magnetic resonance imaging-targeted prostate biopsy[J]. Asian Journal of Andrology, 2019,22(4):131-137.
[5] Rillig A, Bellmann B, Skurk C, et al. Left atrial appendage angiography is associated with the incidence and number of magnetic resonance imaging-detected brain lesions after percutaneous catheter-based left atrial appendage closure[J]. Heart Rhythm, 2018,15(1):3.
[6] Li T G, Zhang Y Y, Nie F, et al. Diagnosis of foetal vein of galen aneurysmal malformation by ultrasound combined with magnetic resonance imaging:a case series[J]. BMC Medical Imaging, 2020,20(1):232-239.
[7] Zhi X, Cai L, Guo N, et al. Discussion on brain structure and function in schizophrenia by multimodal magnetic resonance imaging[J].Journal of Medical Systems, 2019,43(4):23-28.
[8] 郭利, 戴楠. 冠状动脉疾病患者血清IL-12、IL-35水平与ox-LDL及冠状动脉狭窄程度的关系[J]. 中国临床研究, 2018,31(9):32-35.
[9] 李玉, 李永, 张建国, 等. 脑胶质瘤组织中趋化因子7的表达及其与病理、磁共振成像瘤周水肿的关系[J]. 中华实验外科杂志, 2018,35(3):547-549.
[10] Wang Q, Lei D, Yuan Y, et al. Accuracy of magnetic resonance imaging texture analysis in differentiating low-grade from high-grade gliomas:systematic review and meta-analysis[J]. BMJ Open, 2019,9(9):27144.
[11] Shibata D, Suchy-Dicey A, Carty C, et al. Lifestyle risk factors and findings on brain magnetic resonance imaging of older adult American Indians:the strong heart study[J]. Neuroepidemiology, 2019,53(3-4):1-7.
[12] Del C F, Salesov E, Joerger F, et al. Perfusion-weighted and diffusion-weighted magnetic resonance imaging of the liver, spleen, and kidneys of healthy adult male cats[J]. American Journal of Veterinary Research, 2019,80(2):159-167.
[13] 段圣杰, 尚进林, 琚小红, 等. 急性脑梗死患者血清内皮素、IL-10及hs-CRP水平与神经功能缺损的相关性研究[J]. 中华生物医学工程杂志, 2018,24(2):116-120.
[14] Xia H, Ke S C, Qian R R, et al. Comparison between abdominal ultrasound and nuclear magnetic resonance imaging detection of placenta accreta in the second and third trimester of pregnancy[J]. Medicine, 2020,99(2):17908.
[15] Bernal J, Kushibar K, Asfaw D S, et al. Deep convolutional neural networks for brain image analysis on magnetic resonance imaging:a review[J]. Artificial Intelligence in Medicine, 2019,95(4):64-81.
[16] Wu W P, Wu H K, Chen C J, et al. Higher underestimation of tumour size post-neoadjuvant chemotherapy with breast magnetic resonance imaging (MRI)-A concordance comparison cohort analysis[J]. PLoS One, 2019,14(10):222917.
[17] 张晓星, 李跃华. 磁共振技术在脑胶质瘤术前分级中的应用进展[J]. 中国医学计算机成像杂志, 2019,25(3):326-331.
[18] Stephanie W, Lesley M P, Adam O, et al. Multicentre study of perfusion magnetic resonance imaging in paediatric brain tumours[J]. Neuro-Oncology, 2019,12(4):10.