子宫动脉血流多普勒参数结合血清SDC-1、VEGF-A对子宫内膜异位症的诊断价值及相关性分析

doi:10.7517/issn.1674-0475.201219

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (4): 550-555.DOI: 10.7517/issn.1674-0475.201219

子宫动脉血流多普勒参数结合血清SDC-1、VEGF-A对子宫内膜异位症的诊断价值及相关性分析

卢祥章, 邓艳君

广州市花都区妇幼保健院/胡忠医院, 广东广州 510800

收稿日期:2020-12-21 出版日期:2021-07-15 发布日期:2021-07-20
通讯作者: 邓艳君

Diagnostic Value and Correlation Analysis of Uterine Artery Blood Flow Doppler Parameters Combined with Serum SDC-1 and VEGF-A in Endometriosis

LU Xiangzhang, DENG Yanjun

Huadu District Women and Children's Hospital/Huzhong Hospital, Guangzhou 510800, Guangdong, P. R. China

Received:2020-12-21 Online:2021-07-15 Published:2021-07-20

摘要/Abstract

摘要： 本研究主要探讨子宫动脉血流多普勒参数结合血清多配体蛋白聚糖-1（SDC-1）、血管内皮生长因子-A（VEGF-A）对子宫内膜异位症（EMS）的诊断价值及其与临床病理参数关系。选取102例子宫内膜异位症（EMS）患者作为研究组，另选取同期腹部包块但非EMS患者102例作为对照组。研究结果发现，子宫动脉血流多普勒参数（PSV、EDV、RI、PI）、血清SDC-1、VEGF-A与EMS显著相关，PSV、EDV与血清SDC-1、VEGF-A呈负相关，RI、PI与血清SDC-1、VEGF-A呈正相关，且各项指标联合诊断EMS的AUC为0.925，最佳诊断敏感度、特异度分别为80.39%、90.20%。研究结果证实子宫动脉血流多普勒参数、血清SDC-1、VEGF-A联合在EMS诊断方面具有较高应用价值。

关键词: 子宫内膜异位症, 子宫动脉血流多普勒参数, 多配体蛋白聚糖-1, 血管内皮生长因子-A, 临床病理参数

Abstract: The purpose of this study was to investigate the diagnostic value of Doppler parameters of uterine artery combined with serum syndecan-1 (SDC-1), vascular endothelial growth factor-A (VEGF-A) in the diagnosis of endometriosis (EMS) and the relationship between them and clinical pathological parameters. One hundred and two patients with endometriosis (EMS) were selected as the study group, and 102 patients with abdominal mass but not EMS were selected as control group. The results showed that the Doppler parameters of uterine artery blood flow (PSV, EDV, RI, PI), serum SDC-1, VEGF-A were significantly correlated with EMS, PSV EDV was negatively correlated with serum SDC-1 and VEGF-A, RI and PI were positively correlated with serum SDC-1 and VEGF-A, and AUC of EMS was 0.925 for combined diagnosis of each index, and the best sensitivity and specificity were 80.39% and 90.20%, respectively. These results can confirm that the combination of Doppler parameters of uterine artery, serum sdc-1 and VEGF-A has a high value in EMS diagnosis.

Key words: endometriosis, uterine artery blood flow Doppler parameters, syndecan-1, vascular endothelial growth factor-A, clinicopathological parameters

卢祥章, 邓艳君. 子宫动脉血流多普勒参数结合血清SDC-1、VEGF-A对子宫内膜异位症的诊断价值及相关性分析[J]. 影像科学与光化学, 2021, 39(4): 550-555.

LU Xiangzhang, DENG Yanjun. Diagnostic Value and Correlation Analysis of Uterine Artery Blood Flow Doppler Parameters Combined with Serum SDC-1 and VEGF-A in Endometriosis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(4): 550-555.

参考文献

[1] Fung J N, Montgomery G W. Genetics of endometriosis:state of the art on genetic risk factors for endometriosis[J]. Best Practice & Research Clinical Obstetrics & Gynaecology, 2018,50(1):61-71.
[2] 李薇薇, 郭艺红. 子宫内膜异位症患者生育力保护[J]. 生殖医学杂志, 2018,27(6):595-600.
[3] 张玉娟, 林琪, 肖晓君, 等. 超声诊断深部浸润型子宫内膜异位症累及盆腔组织[J]. 中国医学影像技术, 2018,34(4):573-576.
[4] 王笑楠, 汪旭, 孙明军, 等. 超声内镜诊断肠道子宫内膜异位症的临床价值[J]. 中国医科大学学报, 2018,47(11):82-84.
[5] Cicinelli E, Trojano G, Mastromauro M, et al. Higher prevalence of chronic endometritis in women with endometriosis:a possible etiopathogenetic link[J]. Fertility Sterility, 2017,108(2):289-295.
[6] 赵淑芬, 曹华. 腹腔镜术联合达菲林治疗子宫内膜异位症的临床疗效及对患者血清IL-6、Syndecan-1表达的影响[J]. 中国妇幼保健, 2018,33(12):28-31.
[7] Rashidi B H, Sarhangi N, Aminimoghaddam S, et al. Association of vascular endothelial growth factor (VEGF) Gene polymorphisms and expression with the risk of endometriosis:a case-control study[J]. Molecular Biology Reports, 2019,46(3):3445-3450.
[8] Danastas K, Miller E J, Hey-Cunningham A J, et al. Expression of vascular endothelial growth factor a isoforms is dysregulated in women with endometriosis[J]. Reproduction Fertility & Development, 2018,30(4):651-657.
[9] 郎景和, 周应芳, 张震宇, 等. 2015年子宫内膜异位症的诊治指南专家解读[J]. 中华妇产科杂志, 2017,52(12):857-861.
[10] Centini G, Afors K, Alves J, et al. Effect of anterior compartment endometriosis excision on infertility[J]. Jsls Journal of the Society of Laparoendoscopic Surgeons, 2018,22(4):pii:e2018.00067.
[11] 托娅, 杨菁, 陈秀娟, 等. CYP19A1、GSTM1、GSTT1和GSTP1基因多态性与子宫内膜异位症患者发病的相关研究[J]. 中华医学杂志, 2019,99(7):515-519.
[12] Carla T, D'Hooghe T. Endometriosis and infertility:insights into the causal link and management strategies[J]. Best Practice & Research Clinical Obstetrics & Gynaecology, 2018,51(1):25-33.
[13] 郭书焕. 腹腔镜诊断和治疗子宫内膜异位症及不孕症的临床疗效研究[J]. 临床研究, 2018,26(10):11-13.
[14] 宋方田. 子宫内膜异位症腹腔镜诊断与病理诊断之间的差异及相关因素分析[J]. 中国医药指南, 2018,16(4):66-67.
[15] 黄祚. 摆动宫颈后子宫动脉多普勒参数在子宫内膜异位症诊断中的价值[D]. 苏州:苏州大学, 2016.
[16] 汪军虎, 王富丽, 曹利利. 彩色多普勒超声对剖宫产腹壁子宫内膜异位症的诊断价值[J]. 贵州医药, 2020,44(1):118-119.
[17] 武媛媛. 彩色多普勒超声对剖宫产腹壁子宫内膜异位症的诊断效果分析[J]. 中国医疗器械信息, 2018,24(22):145-146.
[18] 俞菊红. 子宫内膜异位症患者盆腔痛与子宫内膜氧化应激、血流动力学指标的关系[J]. 浙江医学, 2018,40(12):1328-1330, 1337.
[19] 张晓芳. 彩色多普勒超声在腹壁瘢痕处子宫内膜异位症诊断中的应用[J]. 中国医药指南, 2019,17(17):122-123.
[20] 贾晓慧, 周晓丽, 张丽丽. 不同临床分期子宫内膜异位症患者血清MMP-9, sHLA-G, SDC-1水平变化及临床意义[J]. 实验与检验医学, 2020,38(2):323-325.
[21] 陆月梅, 卢红, 刘娅, 等. 子宫内膜异位症患者病灶组织和血清VEGF-A、CA125表达变化及其意义[J]. 山东医药, 2017,57(3):81-83.
[22] Wang S, Zhang X, Wang G, et al. Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells[J]. BMC Cancer, 2019,19(1):1160.
[23] 郭路路, 王伟. VEGF-A在子宫内膜异位症中的研究进展[J]. 国际妇产科学杂志, 2018,45(1):111-114.
[24] 徐敏, 季新梅, 朱春仁. 定坤丹联合米非司酮治疗子宫内膜异位症[J]. 中国临床研究, 2019,32(4):556-559.

子宫动脉血流多普勒参数结合血清SDC-1、VEGF-A对子宫内膜异位症的诊断价值及相关性分析

Diagnostic Value and Correlation Analysis of Uterine Artery Blood Flow Doppler Parameters Combined with Serum SDC-1 and VEGF-A in Endometriosis

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价