肌骨超声对类风湿关节炎疾病分期的评估价值及血清SOD、PCSK9表达的关联性

doi:10.7517/issn.1674-0475.210109

摘要/Abstract

摘要： 本研究探讨肌骨超声对类风湿关节炎疾病分期的评估价值及类风湿关节炎与血清超氧化物歧化酶（SOD）、前蛋白转化酶枯草溶菌素9（PCSK9）表达的关系。选取类风湿关节炎患者140例作为观察组，同时选取体检健康者100例作为对照组，检测两组血清SOD、PCSK9的表达水平，给予肌骨超声检查。结果显示：观察组血清SOD的表达水平明显低于对照组，而PCSK9的表达水平明显高于对照组（P<0.05）；观察组中高活动疾病组超声评分明显高于低活动疾病组（P<0.05）；超声评分诊断中高活动疾病组的ROC曲线下面积为0.824，P<0.05；中高活动疾病组TC、TG和PCSK9明显高于低活动疾病组，而SOD明显低于低活动疾病组（P<0.05）；超声评分与DAS28评分、SOD、PCSK9呈正相关关系（P<0.05）；多元线性回归分析结果显示：TC、DAS28评分、SOD和PCSK9与超声评分有关（P<0.05）。因此，肌骨超声在评估类风湿关节炎疾病分期方面有一定价值，其与血清SOD、PCSK9的表达水平呈正相关关系。

关键词: 肌骨超声, 类风湿关节炎, 疾病分期, 超氧化物歧化酶, 前蛋白转化酶枯草溶菌素9

Abstract: The purpose of this study is to investigate the value of musculoskeletal ultrasound in the evaluation of internal rheumatoid arthritis disease staging and the relationship with the expression of serum superoxide dismutase (SOD) and proprotein convertase subtilisin/kexin type 9 (PCSK9). A total of 140 patients with rheumatoid arthritis treated were selected as the observation group, and 100 healthy people were selected as the control group. The expression of serum SOD and PCSK9 in the two groups were detected, the patients in the observation group were given musculoskeletal ultrasound. The results showed that the serum SOD in the observation group was significantly lower than that in the control group, while PCSK9 was significantly higher than that of the control group (P<0.05). In the observation group, the ultrasonic score of the moderate and high activity disease group was significantly higher than that of the low activity group. The area under the ROC curve of ultrasound score in the diagnosis of moderate and high activity diseases was 0.824 (P<0.05). The TC, TG and PCSK9 of moderate and high activity disease group were significantly higher than those of low activity disease group, while SOD was significantly lower than that of low activity disease group (P<0.05). Ultrasound score was positively correlated with DAS28 score, SOD and PCSK9 (P<0.05). Multiple linear regression analysis showed that TC, DAS28 score, SOD and PCSK9 were related to ultrasound score (P<0.05). Therefore, musculoskeletal ultrasound has a certain value in the evaluation of rheumatoid arthritis disease staging, which is positively correlated with serum SOD and PCSK9 levels.

Key words: musculoskeletal ultrasound, internal rheumatoid arthritis, disease stage, superoxide dismutase, proprotein convertase subtilisin/kexin type 9

朱敏, 刘佩, 胡晓莉. 肌骨超声对类风湿关节炎疾病分期的评估价值及血清SOD、PCSK9表达的关联性[J]. 影像科学与光化学, 2021, 39(5): 642-646.

ZHU Min, LIU Pei, HU Xiaoli. The Value of Musculoskeletal Ultrasound in the Evaluation of Rheumatoid Arthritis Disease Staging and the Correlation of Serum SOD and PCSK9 Expression[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 642-646.

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