CTPI参数、sdLDL-C、Annexin A2、Hcy与急性脑梗死病情程度关联性及评估阿替普酶静脉溶栓效果价值

doi:10.7517/issn.1674-0475.210111

摘要/Abstract

摘要： 本文探讨头颅CT灌注成像（CTPI）联合小而密低密度脂蛋白胆固醇（sdLDL-C）、膜联蛋白A2（Annexin A2）、同型半胱氨酸（Hcy）与急性脑梗死（ACI）病情程度关联性及评估阿替普酶静脉溶栓效果价值。结果发现CTPI参数[脑血流量（CBF）、脑血容量（CBV）、达峰时间（TTP）、平均通过时间（MTT）]以及血清sdLDL-C、Annexin A2、Hcy水平与ACI患者病情程度显著相关（P<0.05）；CTPI参数与血清sdLDL-C、Annexin A2、Hcy间存在密切相关性（P<0.05）；入院时、溶栓后CBV、CBF、MTT、TTP、sdLDL-C、Annexin A2、Hcy评估的AUC均在0.7以上，均具有良好评估效能，尤其是溶栓后各指标联合评估溶栓效果的AUC为0.929。这些结果可以证实CTPI参数、sdLDL-C、Annexin A2、Hcy与ACI病情程度显著相关，溶栓后各指标联合在评估溶栓效果方面具有较高应用价值，可为临床制定治疗方案提供重要参考。

关键词: 急性脑梗死, 头颅CT灌注成像, 小而密低密度脂蛋白胆固醇, 膜联蛋白A2, 同型半胱氨酸

Abstract: The purpose of this study is to investigate the relationship between CT perfusion imaging (CTPI) combined with small and dense low density lipoprotein cholesterol (sdLDL-C), Annexin A2, and homocysteine (Hcy) and the severity of acute cerebral infarction (ACI), and to evaluate the value of intravenous thrombolytic effect of alteplase. The results of the study found that CTPI parameters[cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), mean transit time (MTT)] were significantly correlated with the severity of ACI patients, as well as the serum sdLDL-C, Annexin A2 and Hcy levels (P<0.05). There was a significant correlation between CTPI parameters and serum sdLDL-C, Annexin A2, and Hcy (P<0.05). The AUC evaluated by CBV, CBF, MTT, TTP, sdLDL-C, Annexin A2, and Hcy at admission and after thrombolysis were all above 0.7, and they all had good evaluation performance, especially after thrombolysis, the AUC of the combined evaluation of thrombolytic effect was 0.929. These results can confirm that CTPI parameters, sdLDL-C, Annexin A2, Hcy are significantly related to the severity of ACI. The combination of various indicators after thrombolysis has high application value in evaluating the effect of thrombolysis, and can provide an important reference for clinical treatment plans.

Key words: acute cerebral infarction, head CT perfusion imaging, small and dense low density lipoprotein cholesterol, Annexin A2, homocysteine

徐燕, 高阳. CTPI参数、sdLDL-C、Annexin A2、Hcy与急性脑梗死病情程度关联性及评估阿替普酶静脉溶栓效果价值[J]. 影像科学与光化学, 2021, 39(5): 671-677.

XU Yan, GAO Yang. Correlation between CTPI Parameters, sdLDL-C, Annexin A2, Hcy and the Severity of Acute Cerebral Infarction and the Value of Evaluating the Intravenous Thrombolytic Effect of Alteplase[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 671-677.

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