影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (5): 684-688.DOI: 10.7517/issn.1674-0475.210119

• 综述与论文 • 上一篇    下一篇

HER-2蛋白表达与多层螺旋CT胃癌征象相关性分析及应用

李玉珠1, 李亚平1, 李彦良2   

  1. 1. 招远市人民医院普通外科一病区, 山东 招远 265499;
    2. 山东省肿瘤医院胃肠肿瘤外科, 山东 济南 250000
  • 收稿日期:2021-01-22 发布日期:2021-09-13
  • 通讯作者: 李彦良

Correlation Analysis and Clinical Application of HER-2 Protein Expression with Multi-slice Spiral CT Signs of Gastric Cancer

LI Yuzhu1, LI Yaping1, LI Yanliang2   

  1. 1. Department of General Surgery, Zhaoyuan People's Hospital, Zhaoyuan 265499, Shandong, P. R. China;
    2. Department of Gastrointestinal Tumor, Shandong Cancer Hospital, Jinan 250000, Shandong, P. R. China
  • Received:2021-01-22 Published:2021-09-13

摘要: 本研究探讨人类表皮生长因子受体-2(HER-2)蛋白表达与多层螺旋CT(MSCT)胃癌征象的关系。采用回顾性研究方法,选取胃癌患者134例,采用免疫组化染色法检测HER-2表达情况,分析HER-2表达与临床病理及MSCT征象关系。结果显示,高分化组织HER-2阳性表达率为57.41%,高于中低分化组织(P<0.05);有淋巴结转移组织HER-2阳性表达率为48.28%,高于无淋巴结转移组织(P<0.05);HER-2阳性表达病灶静脉期CT值为(87.82±14.45)HU,明显低于HER-2阴性表达病灶(P<0.05);HER-2表达(+++)组织高分化比例为84.62%,高于HER-2表达(++)组织(P<0.05)。研究证实HER-2蛋白表达胃癌分化、淋巴结转移有一定关系,同时与MSCT静脉期CT值有关。

关键词: 人类表皮生长因子受体-2, 多层螺旋CT, 胃癌

Abstract: The purpose of this study was to investigate the relationship between the expression of human epidermal growth factor receptor-2 (HER-2) protein and multi-slice spiral CT (MSCT) signs of gastric cancer. A retrospective study was conducted, 134 cases of gastric cancer patients were selected, the expression of HER-2 was detected by immunohistochemical staining, and the relationship between HER-2 expression and clinicopathological and MSCT signs was analyzed. The results show that the positive expression rate of HER-2 in high differentiated tissues was 57.41%, which was higher than that in low and moderately differentiated tissues (P<0.05). The positive expression rate of HER-2 in tissues with lymph node metastasis was 48.28%, which was higher than that in tissues without lymph node metastasis (P<0.05). The CT value of HER-2 positive expression lesions in venous phase was (87.82±14.45) HU, which was significantly lower than that of HER-2 negative expression lesions (P<0.05). The proportion of highly differentiated tissues with HER-2 expression (+++) was 84.62%, which was higher than that of HER-2 (++) (P<0.05). This study confirmed that HER-2 protein expression is related to gastric cancer differentiation and lymph node metastasis, and is related to the CT value of MSCT venous phase.

Key words: human epidermal growth factor receptor-2, multislice spiral CT, gastric cancer