影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (5): 727-731.DOI: 10.7517/issn.1674-0475.210310

• 综述与论文 • 上一篇    下一篇

US-FNAB、血清TSH、TTF-1诊断甲状腺微小癌价值及与病理因素关系

邱爽, 王庆文, 张倩, 颜慧珊, 廖倩   

  1. 唐山工人医院超声科, 河北 唐山 063000
  • 收稿日期:2021-03-30 发布日期:2021-09-13
  • 通讯作者: 王庆文

The Value of US-FNAB, Serum TSH, TTF-1 in the Diagnosis of Thyroid Microcarcinoma and Its Relationship with Pathological Factors

QIU Shuang, WANG Qingwen, ZHANG Qian, YAN Huishan, LIAO Qian   

  1. Department of Ultrasound, Tangshan Gongren Hospital, Tangshan 063000, Hebei, P. R. China
  • Received:2021-03-30 Published:2021-09-13

摘要: 选择甲状腺微小癌(TMC)患者106例作为研究组,另选择同期甲状腺良性肿瘤患者94例作为对照组。均接受超声引导下细针穿刺活检(US-FNAB)、血清促甲状腺激素(TSH)、甲状腺转录因子-1(TTF-1)检查,发现US-FNAB阳性率及血清TSH、TTF-1与癌胚抗原(CEA)、半乳糖血凝素-3(Gal-3)、细胞角蛋白19(CK-19)、肿瘤分期、淋巴结转移、甲状腺癌侵袭呈正相关,与分化程度呈负相关(P<0.05);US-FNAB及血清TSH、TTF-1联合诊断TMC的AUC最大,为0.892。由此可见,US-FNAB及血清TSH、TTF-1均与TMC患者病理因素相关,三者联合检测可为临床诊断TMC、评估TMC病情程度提供重要依据。

关键词: 超声引导下细针穿刺活检, 促甲状腺激素, 甲状腺转录因子-1, 甲状腺微小癌, 病理因素

Abstract: A total of 106 patients with thyroid micro carcinoma (TMC) were selected as the study group, and 94 patients with benign thyroid tumors during the same period were selected as the control group. All patients underwent ultrasound-guided fine needle aspiration biopsy (US-FNAB), serum thyroid stimulating hormone (TSH), thyroid transcription factor-1 (TTF-1) examination, and found the positive rate of US-FNAB, serum TSH, TTF-1 and cancer embryonic antigen (CEA), galectin-3 (Gal-3), cytokeratin 19 (CK-19), tumor stage, lymph node metastasis, thyroid cancer invasion are positively correlated, and negatively correlated with the degree of differentiation (P<0.05); US-FNAB, serum TSH, TTF-1 combined diagnosis of TMC with the highest AUC, which is 0.892. It can be seen that US-FNAB, serum TSH, and TTF-1 are all related to the pathological factors of TMC patients, and the combined detection of the three can provide an important basis for clinical diagnosis of TMC and assessment of the severity of TMC.

Key words: ultrasound-guided fine needle aspiration biopsy, thyroid stimulating hormone, thyroid transcription factor-1, thyroid micro carcinoma, pathological factors