PET/CT结合血清CEA、VEGF诊断胃癌的价值

doi:10.7517/issn.1674-0475.211108

摘要/Abstract

摘要： 本文探讨正电子发射断层显像/计算机断层扫描(PET/CT)结合血清癌胚抗原(CEA)、血管内皮生长因子(VEGF)诊断胃癌的价值。选取疑似胃癌患者108例,分析PET/CT诊断胃癌的价值,同时比较胃癌伴和不伴淋巴结转移患者血清CEA、VEGF差异。108例疑似胃癌患者中,经病理学确诊胃癌69例;PET/CT诊断与病理结果Kappa值为0.764(P＜0.05),一致性较好;胃癌伴淋巴结转移患者血清CEA和VEGF明显高于不伴淋巴结转移患者(P＜0.05);PET/CT结合血清CEA、VEGF诊断胃癌伴淋巴结转移的灵敏性和阴性预测值分别为90.00%和90.32%,高于PET/CT单独诊断,但差异无统计学意义(P>0.05)。PET/CT诊断胃癌有较好的价值,CEA、VEGF诊断胃癌伴淋巴结转移有一定应用价值。

关键词: 正电子发射断层显像/计算机断层扫描, 癌胚抗原, 血管内皮生长因子, 胃癌

Abstract: This article explored the value of positron emission tomography/computed tomography (PET/CT) combined with serum carcinoembryonic antigen (CEA) and vascular endothelial growth factor (VEGF) in the diagnosis of gastric cancer. Chosen 108 patients with suspected gastric cancer treated, and analyzed the value of PET/CT in the diagnosis of gastric cancer, then compared the differences of serum CEA and VEGF between gastric cancer with and without lymph node metastasis. Among the 108 suspected cases, Sixty-nine patients with gastric cancer were diagnosed pathologically. The kappa value of PET/CT diagnosis and pathological results was 0.764 (P<0.05) and consistency well. The serum CEA and VEGF in gastric cancer patients with lymph node metastasis were significantly higher than those in patients without lymph node metastasis (P<0.05). The sensitivity and negative predictive value of PET/CT combined with serum CEA and VEGF in the diagnosis of gastric cancer with lymph node metastasis were 90.00% and 90.32% respectively, which was higher than those of PET/CT diagnosis alone, while the difference was not statistically significant (P>0.05). PET/CT has good value in the diagnosis of gastric cancer, CEA and VEGF could have a certain application value in the diagnosis of gastric cancer with lymph node metastasis.

Key words: positron emission tomography/computed tomography, carcinoembryonic antigen, vascular endothelial growth factor, gastric cancer

侯先存, 周青, 刘莉, 张研菊, 许雪宁. PET/CT结合血清CEA、VEGF诊断胃癌的价值[J]. 影像科学与光化学, 2022, 40(3): 531-534.

HOU Xiancun, ZHOU Qing, LIU Li, ZHANG Yanju, XU Xuening. The Value of PET/CT Combined with Serum CEA and VEGF in the Diagnosis of Gastric Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(3): 531-534.

参考文献

[1] 黄明亮, 赵达, 胡玉萍, 等. 血管内皮生长因子与胃癌关系的研究进展[J]. 中华实用诊断与治疗杂志, 2019,33(11):1131-1134.
[2] 杨婉玲, 付秀华, 顾岩. 联合检测血管内皮生长因子和癌胚抗原对诊断良、恶性胸腔积液的价值[J]. 广东医学, 2020,41(7):697-701.
[3] 孙国钢, 宋新江. 转化生长因子-β1、缺氧诱导因子-1α、血管内皮生长因子、癌胚抗原、糖类抗原199在结直肠癌根治术后复发转移中的预测价值[J]. 中国医师杂志, 2020,22(12):1888-1892.
[4] 林琳, 兰莉, 杨超, 等. 哈尔滨市居民2015-2017年胃癌流行病学分析[J]. 中国公共卫生管理, 2020,36(1):110-112, 120.
[5] 严洁, 李晓琳, 徐慧. ¹⁸F-FDG PET/CT显像联合肿瘤标志物检测在宫颈癌诊断中的应用[J]. 中国CT和MRI杂志, 2021,19(1):155-157.
[6] Obana A, Komatsu N, Aiba K, et al. A case of long-term survival after splenectomy for solitary splenic metastasis from gastric cancer[J]. World Journal of Surgical Oncology, 2020,18(1):250.
[7] 毛海波, 朱国栋, 方润娅, 等. 血管生成素-2、血管内皮生长因子、糖类抗原199及癌胚抗原对结肠癌诊断和复发转移的预测价值[J]. 实用医学杂志, 2019,35(3):428-432.
[8] Yaxley J W, Raveenthiran S, Nouhaud F X, et al. Risk of metastatic disease on 68 gallium-prostate-specific membrane antigen positron emission tomography/computed tomography scan for primary staging of 1253 men at the diagnosis of prostate cancer[J]. BJU International, 2019,124(3):401-407.
[9] 中华医学会核医学分会. 淋巴瘤¹⁸F-FDG PET/CT及PET/MR显像临床应用指南(2021版)[J]. 中华核医学与分子影像杂志, 2021,41(3):161-169.
[10] 郭飞虎, 成伟华, 费月英, 等. Na¹⁸F PET/CT用于恶性肿瘤骨转移诊断的Meta分析[J]. 标记免疫分析与临床, 2019,26(5):786-794, 836.
[11] 邓先琴. PET/CT对结直肠癌术后复发、转移的诊断价值[D]. 广州:广州中医药大学, 2012.
[12] 郝少雨, 张百江, 张为迪, 等. PET/CT对NSCLC前哨淋巴结转移预测价值的分析[J]. 中华肿瘤防治杂志, 2012,19(14):1101-1102, 1108.
[13] 李良, 顾慧珍. 血管内皮生长因子-A和α-Adducin在胃癌组织中的表达及其与临床病理特征和预后的相关性[J]. 国际消化病杂志, 2019,39(3):216-221.
[14] 唐欢, 奚维东, 夏敏, 等. 胃癌组织中Podoplanin、血管内皮生长因子-C表达水平及临床意义[J]. 实用医院临床杂志, 2019,16(5):192-194.
[15] 丁玲, 张伟华, 马靖, 等. PET/CT对981例肺结节的良恶性诊断价值分析[J]. 癌症进展, 2017,15(3):277-279.