影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (3): 545-549.DOI: 10.7517/issn.1674-0475.211122

• 综述与论文 • 上一篇    下一篇

超声联合CA125、HE4检测对卵巢性索间质肿瘤的诊断分析

周利, 宣之东, 李秀娟   

  1. 沧州市中心医院超声诊断三科, 河北 沧州 061011
  • 收稿日期:2021-11-10 出版日期:2022-05-15 发布日期:2022-05-27

The Diagnostic Analysis of Ultrasound Combined with CA125 and HE4 Detection in Ovarian Sex Cord Stromal Tumor

ZHOU Li, XUAN Zhidong, LI Xiujuan   

  1. The Third Department of Ultrasound Diagnosis of Cangzhou Central Hospital, Cangzhou 061011, Hebei, P. R. China
  • Received:2021-11-10 Online:2022-05-15 Published:2022-05-27

摘要: 本文探讨超声联合血清糖类抗原125(CA125)、人附睾蛋白4(HE4)诊断卵巢性索间质肿瘤(OSCST)的临床价值。选取经手术后病理学检查证实的OSCST患者87例作为研究对象(OSCST组)、90例良性卵巢囊肿患者作为对照组,分析两组患者术前经阴道彩色多普勒超声(CDFI)影像学特征及血清CA125、HE4水平(化学发光法测定),采用受试者操作特征(ROC)曲线对各项指标的诊断价值进行分析。结果显示,OSCST组的血清CA125、HE4水平显著高于对照组,差异具有统计学意义(P<0.05);OSCST组病灶后方回声衰减较对照组更加明显(P<0.05),OSCST组患者病灶CDFI血流分级中Ⅱ级、Ⅲ级患者占比显著高于对照组(P<0.05);超声联合血清CA125、HE4鉴别诊断OSCST与卵巢良性囊肿的灵敏度为85.06%、特异度为80.00%、漏诊率为14.94%、误诊率为20.00%。超声联合血清CA125、HE4鉴别诊断OSCST与卵巢良性囊肿在临床长具有较高的灵敏度和特异度,较3种方法单独应用能显著提高诊断的准确性。

关键词: 经阴道彩色多普勒超声, 糖类抗原, 人附睾蛋白4, 卵巢性索间质肿瘤

Abstract: This study explored the clinical value of ultrasound combined with serum carbohydrate antigen 125 (CA125) and human epididymal protein 4 (HE4) in ovarian sex cord stromal tumors (OSCST). Selected 87 OSCST patients (OSCST group) and 90 patients (control group) with benign ovarian cysts confirmed by postoperative pathological examination, and analyzed the preoperative transvaginal color doppler ultrasound (CDFI) imaging characteristics and serum CA125 and HE4 levels (determined by chemiluminescence method) of the two groups. The diagnostic value of each index was analyzed by receiver operator characteristic (ROC) curve. The results showed that the levels of serum CA125 and HE4 in the OSCST group were significantly higher than those in the control group (P<0.05). The echo attenuation behind the lesions in the OSCST group was more significant than that in the control group (P<0.05). The CDFI blood flow of the lesions in the OSCST group the grade Ⅱ and grade Ⅲ patients in the classification was higher than those in the control group (P<0.05). The sensitivity of ultrasound combined with serum CA125 and HE4 in the differential diagnosis of OSCST and benign ovarian cysts was 85.06%, specificity was 80.00%, missed diagnosis rate was 14.94%, and misdiagnosis rate was 20.00%. Ultrasound combined with serum CA125 and HE4 in the differential diagnosis of OSCST and ovarian benign cysts has higher clinical sensitivity and specificity. Compared with the three methods alone, it can significantly improve the accuracy of diagnosis.

Key words: transvaginal color Doppler ultrasound, carbohydrate antigen, human epididymal protein 4, ovarian sex cord stromal tumors