影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (3): 453-458.DOI: 10.7517/issn.1674-0475.211142

• 综述与论文 • 上一篇    下一篇

CRSwNP患者并发AAHR与鼻窦CT评分、EOS计数的关系

谢焕清1, 许国珍2   

  1. 1. 苏州大学附属独墅湖医院耳鼻咽喉科, 江苏 苏州 215100;
    2. 苏州科技城医院耳鼻咽喉科, 江苏 苏州 215153
  • 收稿日期:2021-11-15 出版日期:2022-05-15 发布日期:2022-05-27

The Relationship between Sinus CT Score, EOS Count and CRSwNP Patients Complicated with AAHR

XIE Huanqing1, XU Guozhen2   

  1. 1. The Department of Otorhinolaryngology, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215100, Jiangsu, P. R. China;
    2. The Department of Otorhinolaryngology, Suzhou Science & Technology Town Hospital, Suzhou 215153, Jiangsu, P. R. China
  • Received:2021-11-15 Online:2022-05-15 Published:2022-05-27

摘要: 本研究探讨鼻窦CT评分、嗜酸性粒细胞(EOS)计数在慢性鼻窦炎伴鼻息肉(CRSwNP)患者并发无症状气道高反应(AAHR)诊断中的价值。对确诊的127例CRSwNP患者进行临床研究,根据患者是否伴有AAHR分为观察组(71例)和对照组(未出现气道高反应的CRSwNP患者56例);对两组患者进行鼻窦CT三维重建检查和评分,检测两组患者鼻息肉与外周血中EOS水平。观察组患者鼻息肉及外周血组织中的EOS表达水平均高于对照组(P<0.05);鼻息肉组织中的EOS诊断CRSwNP患者并发AAHR的AUC值为0.852;外周血中的EOS诊断CRSwNP患者并发AAHR的AUC值为0.821;观察组患者嗅裂CT评分、筛窦CT评分均显著高于对照组(P<0.05);观察组和对照组的上颌窦CT评分差异无统计学意义(P>0.05);嗅裂CT评分诊断CRSwNP患者并发AAHR的AUC值为0.761;筛窦CT评分诊断CRSwNP患者并发AAHR的AUC值为0.864。并发AAHR的CRSwNP患者病情严重,通过检测EOS表达及进行鼻窦CT评分,对于判断CRSwNP患者是否合并AAHR有一定的价值。

关键词: CT三维重建, 嗜酸性粒细胞, 慢性鼻窦炎, 鼻息肉, 无症状气道高反应, 诊断

Abstract: This study investigated the value of sinus CT score and eosinophil (EOS) count in the diagnosis of chronic rhinosinusitis with nasal polyps (CRSwNP) complicated with asymptomatic airway hyperresponsiveness (AAHR). A clinical study was conducted on 127 confirmed CRSwNP patients, according to whether the patients were accompanied by AAHR, they were divided into observation group (71 cases) and CRSwNP patients without airway hyperresponsiveness (56 cases) as control group. Performed the sinus CT three-dimensional reconstruction and scoring, and detected the levels of EOS in nasal polyps and peripheral blood of the two groups. The expression levels of EOS in nasal polyps and peripheral blood tissues of the observation group were higher than those of the control group (P<0.05). The AUC value of EOS in nasal polyps to diagnose CRSwNP patients complicated with AAHR was 0.852, and in peripheral was 0.821. The CT scores of olfactory cleft and ethmoid sinus in the observation group were significantly higher than those in the control group (P<0.05). There was no significant difference in maxillary sinus CT scores between the observation group and the control group (P>0.05). The AUC value of olfactory fissure CT score in the diagnosis of CRSwNP patients complicated with AAHR was 0.761, and of ethmoid sinus was 0.864. CRSwNP patients complicated with AAHR are serious. The detection of EOS expression and sinus CT scores have a certain value in judging whether CRSwNP patients complicated with AAHR.

Key words: CT three-dimensional reconstruction, eosinophils, chronic sinusitis, nasal polyps, asymptomatic airway hyperresponsiveness, diagnosis