双源CT颅脑灌注成像联合FGF21诊断脑梗死严重程度中的价值分析

doi:10.7517/issn.1674-0475.220620

摘要/Abstract

摘要： 本研究旨在揭示双源CT(DECT)颅脑灌注成像联合成纤维细胞生长因子21(FGF21)诊断脑梗死严重程度的价值。采用DECT颅脑灌注成像对100例急性脑梗死患者进行检查,获取相对脑血流量(rCBF)和相对脑血容量(rCBV)。通过酶联免疫吸附试验法(ELISA)检测100例患者和30例健康体检者的血浆成纤维细胞生长因子21(FGF21)水平。根据美国国立卫生研究院卒中量表(NIHSS)评分将患者分为轻度、中度和重度。通过受试者操作特征(ROC)曲线分析各参数对脑梗死严重程度的诊断价值。rCBF和rCBV水平随着脑梗死严重程度升高而降低(P<0.05)。随着脑梗死严重程度的增加,血浆FGF21水平逐渐升高(F=65.212,P=0.002)。rCBF和rCBV联合血浆FGF21诊断脑梗死严重程度的AUC、敏感性和特异性分别为0.955、84.91%和95.74%。rCBF和rCBV联合血浆FGF21对脑梗死严重程度的诊断价值高于单独诊断。

关键词: 脑梗死, 双源CT颅脑灌注成像, 成纤维细胞生长因子21, 相对脑血流量, 相对脑血容量

Abstract: This study aimed to reveal the value of dual- energy CT (DECT) cranial perfusion imaging combined with fibroblast growth factor 21 (FGF21) in the diagnosis of the severity of cerebral infarction. 100 patients with acute cerebral infarction were examined by DECT cranial perfusion imaging to obtain relative cerebral blood flow (rCBF) and relative cerebral blood volume (rCBV). Plasma fibroblast growth factor 21 (FGF21) levels in 100 patients and 30 healthy subjects were detected by enzyme-linked immunosorbent assay (ELISA). Patients were classified as mild, moderate, and severe according to the National Institutes of Health stroke scale (NIHSS) score. The diagnostic value of each parameter on the severity of cerebral infarction was analyzed by receiver operating characteristic (ROC). The levels of rCBF and rCBV decreased with the increase of cerebral infarction severity (P<0.05). With the increase of the severity of cerebral infarction, the level of plasma FGF21 increased gradually (F=65.212, P=0.002). The AUC, sensitivity and specificity of rCBF and rCBV combined with plasma FGF21 in diagnosing the severity of cerebral infarction were 0.955, 84.91% and 95.74%, respectively. The diagnostic value of rCBF and rCBV combined with plasma FGF21 for the severity of cerebral infarction is higher than that of single diagnosis.

Key words: cerebral infarction, dual- energy CT cranial perfusion imaging, fibroblast growth factor 21, relative cerebral blood flow, relative cerebral blood volume

邓靖, 张鹤龄, 王源江, 谭春苗. 双源CT颅脑灌注成像联合FGF21诊断脑梗死严重程度中的价值分析[J]. 影像科学与光化学, 2022, 40(6): 1444-1448.

DENG Jing, ZHANG Heling, WANG Yuanjiang, TAN Chunmiao. Value of Dual-energy CT Cerebral Perfusion Imaging Combined with FGF21 in the Diagnosis of the Severity of Cerebral Infarction[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1444-1448.

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