关键词: 磁共振成像, 脑叶体积, 脑白质疏松, 阿尔茨海默病, 诊断

Abstract: This study explored the application value of magnetic resonance imaging (MRI) examination of lobe volume changes and leukoaraiosis in the diagnosis of Alzheimer's disease (AD) patients and disease assessment. A total of 90 diagnosed AD patients were selected as the AD group, and 90 volunteers who received physical examinations during the same period were selected as the control group. Both groups underwent MRI examination, and the differences in various indicators and leukoaraiosis (LA) severity grading were compared. The value of each index in the diagnosis of AD patients were analyzed. According to the Clinical Dementia Rating Scale (CDR), the patients were divided into mild, moderate and severe for stratified comparison. The proportion of parietal, occipital and temporal lobe volume in the AD group was smaller than that in the control group (P＜0.05). The measured value of hippocampal height in the AD group was lower than that in the control group (P＜0.05). There was statistically significant difference in LA grade between the AD group and the control group (P＜0.05). The proportion of parietal lobe volume, the proportion of occipital lobe volume, the proportion of temporal lob volume and hippocampal height in patients with severe AD were lower than those in patients with mild to moderate AD (P＜0.05) in the severe AD group. The LA grades of the patients were mainly grade 2 and grade 3, and the patients with mild to moderate AD were mainly grade 0 and grade 1 patients. There was a statistically significant difference in LA grade between the severe AD group and the mild to moderate AD patients (P＜0.05). The lobe volume and hippocampal height of AD patients all changed, and the changes in leukoaraiosis were more obvious. The clinical evaluation of MRI has a certain value.

Key words: magnetic resonance imaging, lobe volume, loose white matter, Alzheimer's disease, diagnosis