3D-ASL评估慢性期脑梗死脑血流量及与认知功能的相关性

doi:10.7517/issn.1674-0475.220708

摘要/Abstract

摘要： 本文研究了3D动脉自旋标记灌注成像(3D-ASL)评估慢性期脑梗死脑血流量(CBF)及与认知功能的相关性。选取64例慢性期脑梗死患者作为慢性期组,同时选取60例急性期脑梗死患者作为急性期组,50例亚急性期脑梗死患者作为亚急性期组,比较三组患侧及健侧CBF、相对脑血流量(rCBF)差异。慢性期组患侧CBF、rCBF明显低于亚急性期组和急性期组(P＜0.05)。慢性期组患者简易智能精神状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分和Fugl-Meyer评分明显低于亚急性期组和急性期组(P＜0.05)。患侧CBF、rCBF与MMSE评分、MoCA评分呈正相关(P＜0.05)。经Logistic回归分析显示:年龄、糖尿病、患侧CBF和rCBF是慢性期脑梗死患者发生认知功能障碍的影响因素(P＜0.05)。慢性期脑梗死患者CBF与患者认知功能相关,3D-ASL评估CBF有助于了解慢性期脑梗死患者认知功能受损情况。

关键词: 3D动脉自旋标记灌注成像, 慢性期, 脑梗死, 脑血流量

Abstract: In this study, 3D arterial spin labeling perfusion imaging (3D-ASL) was used to evaluate cerebral blood flow (CBF) in chronic cerebral infarction and its correlation with cognitive function. 64 patients with chronic cerebral infarction were selected as the chronic group, 60 patients with acute cerebral infarction were selected as the acute group, and 50 patients with subacute cerebral infarction were selected as the subacute group. The CBF and relative cerebral blood flow (rCBF) of the affected side and the healthy side were compared among the three groups. The CBF and rCBF of the affected side in the chronic phase group were significantly lower than those in the acute phase group and the acute phase group (P<0.05). The Mini Mental State Scale (MMSE) and Montreal Cognitive Assessment Scale (MoCA) and Fugl-Meyer score of patients in chronic stage group were significantly lower than those in subacute stage group and acute stage group (P<0.05). Ipsilateral CBF and rCBF were positively correlated with MMSE score and MoCA score (P<0.05). Logistic regression analysis showed that age, diabetes, ipsilateral CBF and rCBF were the influencing factors of cognitive dysfunction in patients with chronic cerebral infarction (P<0.05). CBF is correlated with cognitive function in patients with chronic cerebral infarction. 3D-ASL assessment of CBF is helpful to understand the cognitive function impairment in patients with chronic cerebral infarction.

Key words: 3D arterial spin labeling perfusion imaging, chronic phase, cerebral infarction, cerebral blood flow

孟庆宁, 史纲, 王润强. 3D-ASL评估慢性期脑梗死脑血流量及与认知功能的相关性[J]. 影像科学与光化学, 2022, 40(6): 1433-1437.

MENG Qingning, SHI Gang, WANG Runqiang. Evaluation of Cerebral Blood Flow in Chronic Cerebral Infarction by 3D-ASL and Its Correlation with Cognitive Function[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1433-1437.

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