影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (6): 1621-1627.DOI: 10.7517/issn.1674-0475.220815

• 综述与论文 • 上一篇    下一篇

弥散加权成像和TRIM44在诊断子宫内膜癌及病理分期中的应用

郑小菊1, 单正宜2, 杨贝贝1   

  1. 1. 信阳职业技术学院医学院病理教研室, 河南 信阳 464000;
    2. 青岛大学附属医院病理科, 山东 青岛 266000
  • 收稿日期:2022-08-08 出版日期:2022-11-23 发布日期:2022-11-15
  • 通讯作者: 杨贝贝

Application of Diffusion-weighted Imaging and TRIM44 in the Diagnosis and Pathological Staging of Endometrial Cancer

ZHENG Xiaoju1, SHAN Zhengyi2, YANG Beibei1   

  1. 1. Pathological Teaching and Research Office, Xinyang Vocational and Technical College, Xinyang 464000, Henan, P. R. China;
    2. Pathology Department, The Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, P. R. China
  • Received:2022-08-08 Online:2022-11-23 Published:2022-11-15

摘要: 本文探讨弥散加权成像(DWI)参数联合三结构域蛋白44(TRIM44)基因在子宫内膜癌(EC)病理分期中的诊断价值。本次研究共纳入140例子宫内膜病变患者,均行DWI检查,根据手术病理结果,83例患者确诊为EC(EC组),57例患者确诊为子宫内膜良性病变(良性组)。通过qRT-PCR检测患者血清TRIM44 mRNA水平。结果显示,与良性组比较,EC组的平均表观扩散系数(ADCmean)和最小表观扩散系数(ADCmin)均显著降低,而血清TRIM44 mRNA相对表达量显著升高(P<0.001)。ADCmean、ADCmin与血清TRIM44负相关(r=-0.305、-0.325,P<0.001)。与FIGO Ⅰ期组比较,Ⅱ~Ⅳ期组的ADCmean显著降低,而血清TRIM44 mRNA相对表达量显著升高(P<0.05)。ROC曲线分析显示,ADCmean、ADCmin和血清TRIM44 mRNA相对表达量诊断EC的AUC分别为0.808、0.830和0.818,联合诊断的AUC(0.936)高于单独诊断;ADCmean、ADCmin和血清TRIM44 mRNA相对表达量诊断FIGO Ⅱ~Ⅳ期的AUC分别为0.657、0.632和0.733,联合诊断的AUC(0.769)和特异性(87.50%)高于单独诊断。DWI参数(ADCmean、ADCmin)联合血清TRIM44可提高诊断EC及FIGO分期的准确性。

关键词: 弥散加权成像, 三结构域蛋白44, 子宫内膜癌, 表观扩散系数, FIGO分期

Abstract: This article explored the diagnostic value of diffusion-weighted imaging (DWI) parameters combined with tripartite motif-containing protein 44 (TRIM44) gene in pathological staging of endometrial cancer (EC). A total of 140 patients with endometrial lesions were included in this study, all of whom underwent DWI examination. According to the surgical and pathological results, 83 patients were diagnosed with EC (EC group), and 57 patients were diagnosed with benign endometrial lesions (benign group). Serum TRIM44 mRNA levels of patients were detected by qRT-PCR. The results showed that compared with the benign group, the mean apparent diffusion coefficient (ADCmean) and minimum apparent diffusion coefficient (ADCmin) of the EC group were significantly decreased, while the relative expression of serum TRIM44 mRNA was significantly increased (P<0.001). ADCmean and ADCmin were negatively correlated with serum TRIM44 (r=-0.305, -0.325,P<0.001). Compared with the FIGO stage Ⅰ group, the ADCmean of stage Ⅱ-Ⅳ group was significantly decreased, while the relative expression of serum TRIM44 mRNA was significantly increased (P<0.05). The ROC curve analysis showed that the AUC of ADCmean, ADCmin and serum TRIM44 mRNA relative expression in the diagnosis of EC were 0.808, 0.830 and 0.818, respectively, and the AUC of combined diagnosis (0.936) was higher than that of single diagnosis. The AUC of ADCmean, ADCmin and serum TRIM44 mRNA relative expression in the diagnosis of FIGO stage Ⅱ-Ⅳ were 0.657, 0.632 and 0.733,respectively. The AUC (0.769) and specificity (87.50%) of combined diagnosis were higher than those of single diagnosis. DWI parameters (ADCmean, ADCmin) combined with serum TRIM44 can improve the diagnostic accuracy of EC and FIGO staging.

Key words: diffusion-weighted imaging, tripartite motif-containing protein 44, endometrial cancer, apparent diffusion coefficient, FIGO staging