彩色多普勒超声参数与BRVO合并ME患者病情程度、疗效的关系

doi:10.7517/issn.1674-0475.220824

影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (6): 1412-1416.DOI: 10.7517/issn.1674-0475.220824

彩色多普勒超声参数与BRVO合并ME患者病情程度、疗效的关系

孙红双¹, 尹丹¹, 刘颖¹, 孙红雯¹, 孙霞², 李跃峰¹

1. 衡水市人民医院眼科, 河北衡水 053000;
2. 衡水市人民医院超声二科, 河北衡水 053000

收稿日期:2022-08-11 出版日期:2022-11-23 发布日期:2022-11-15
通讯作者: 李跃峰
基金资助:
衡水市2021年度科技计划项目(2021014087Z)

The Relationship between Color Doppler Ultrasound Parameters and Disease Severity and Curative Effect in Patients with BRVO Combined with ME

SUN Hongshuang¹, YIN Dan¹, LIU Ying¹, SUN Hongwen¹, SUN Xia², LI Yuefeng¹

1. Department of Ophthalmology, Hengshui People's Hospital, Hengshui 053000, Hebei, P. R. China;
2. The Second Department of Ultrasound, Hengshui People's Hospital, Hengshui 053000, Hebei, P. R. China

Received:2022-08-11 Online:2022-11-23 Published:2022-11-15

摘要/Abstract

摘要： 本研究探讨彩色多普勒超声参数与视网膜分支静脉阻塞(BRVO)合并黄斑水肿(ME)患者病情程度、疗效的关系。选取86例BRVO合并ME患者作为研究组,另选取86例单纯BRVO患者作为对照组,均行彩色多普勒超声检查,分析视网膜中央动脉(CRA)及眼动脉(OA)彩色多普勒超声参数[收缩期峰值流速(PSV)、舒张末期流速(EDV)、阻力指数(RI)]与病情程度、疗效的关系。研究组CRA的EDV、PSV、RI低于对照组,且黄斑囊样水肿＜弥漫性水肿＜局限性水肿(P＜0.05)。BRVO合并ME患者CRA的EDV、PSV、RI与病情程度均呈负相关(P＜0.05)。治疗后,治疗有效患者CRA的EDV、PSV、RI高于无效患者,治疗前后差值高于无效患者(P＜0.05)。EDV、PSV、RI差值联合预测BRVO合并ME疗效价值优于单一预测。可见彩色多普勒超声参数与BRVO合并ME患者病情程度、疗效密切相关,可指导临床诊治。

关键词: 视网膜分支静脉阻塞, 黄斑水肿, 彩色多普勒超声, 病情程度

Abstract: This study investigated the relationship between colour Doppler ultrasound parameters and the disease severity and outcome of patients with branch retinal vein occlusion (BRVO) combined with macular oedema (ME). Eighty-six patients with BRVO combined with ME were selected as the study group, and 86 patients with BRVO alone were included as the control group. Colour Doppler ultrasound examinations were performed to analyse the relationship between colour Doppler ultrasound parameters [peak systolic flow velocity (PSV), end-diastolic flow velocity (EDV) and resistance index (RI)] of the central retinal artery (CRA) and ophthalmic artery (OA) and the disease severity and its outcome. The results showed that the EDV, PSV and RI of CRA in the study group were lower than those of the control group, and macular cystoid edema < diffuse < restrictive (P<0.05). EDV, PSV and RI of CRA in patients with BRVO combined with ME were negatively correlated with the degree of disease (P<0.05). The EDV, PSV and RI of CRA were higher in effective patients than in ineffective patients after treatment, and the difference before and after treatment was higher than in ineffective patients (P<0.05). The combined value of EDV, PSV and RI difference predicted the efficacy of BRVO combined with ME better than the single prediction. It can be seen that colour Doppler ultrasound parameters are closely related to the disease severity and efficacy of BRVO combined with ME, which can guide clinical management.

Key words: branch retinal vein occlusion, macular edema, color Doppler ultrasound, disease severity

孙红双, 尹丹, 刘颖, 孙红雯, 孙霞, 李跃峰. 彩色多普勒超声参数与BRVO合并ME患者病情程度、疗效的关系[J]. 影像科学与光化学, 2022, 40(6): 1412-1416.

SUN Hongshuang, YIN Dan, LIU Ying, SUN Hongwen, SUN Xia, LI Yuefeng. The Relationship between Color Doppler Ultrasound Parameters and Disease Severity and Curative Effect in Patients with BRVO Combined with ME[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1412-1416.

参考文献

[1] 赵娟, 毕晓达, 司艳芳, 等. 雷珠单抗注射液治疗非缺血型视网膜分支静脉阻塞黄斑水肿患者的临床研究[J]. 中国临床药理学杂志, 2021, 37(11):1330-1332.
[2] Arroyo J G, Seto B, Yamada K, et al. Rapid reduction of macular edema due to retinal vein occlusion with low-dose normobaric hyperoxia[J]. Graefe’s Archive for Clinical and Experimental Ophthalmology, 2021, 259(8):2113-2118.
[3] 乔灵飞, 姜波, 史春生, 等. 单次康柏西普注射对视网膜分支静脉阻塞继发黄斑水肿病人黄斑区视网膜血流参数的影响[J]. 安徽医药, 2021, 25(4):818-820, 封4.
[4] 马恒哲. 雷珠单抗对视网膜分支静脉阻塞继发黄斑水肿患者视网膜血流密度的影响[J]. 眼科新进展, 2021, 41(9):874-878.
[5] 季红英, 杨林青, 郭黎霞, 等. 视网膜激光联合球内注射雷珠单抗治疗视网膜静脉阻塞黄斑水肿对黄斑区微血管结构变化的影响[J]. 中国医师杂志, 2021, 23(10):1555-1558.
[6] 赵堪兴, 杨培增. 眼科学[M]. 8版. 北京:人民卫生出版社, 2013:210-225.
[7] 庄靖玲. 和血明目片结合雷珠单抗治疗视网膜静脉阻塞合并黄斑水肿临床疗效及安全性研究[J]. 中华中医药学刊, 2021, 39(7):172-175.
[8] Noma H, Yasuda K, Shimura M. Change of cytokines after intravitreal ranibizumab in patients with recurrent branch retinal vein occlusion and macular edema[J]. European Journal of Ophthalmology, 2021, 31(1):204-210.
[9] 褚煜, 喻晓兵, 郑博迪. 深浅血流密度比值与视网膜分支静脉阻塞继发黄斑水肿治疗反应的相关性分析[J]. 中华眼底病杂志, 2021, 37(2):109-114.
[10] Mizui T, Noma H, Yasuda K, et al. Intravitreal ranibizumab reduced ocular blood flow and aqueous cytokine levels and improved retinal morphology in patients with diabetic macular edema[J]. Scientific Reports, 2020, 10(1):21713.
[11] Gok M, Altas H, Kapti H B. The impact of intravitreal dexamethasone implant (Ozurdex^®) on retrobulbar hemodynamics in patients with diabetic macular edema and retinal vein occlusions[J]. Cutaneous and Ocular Toxicology, 2019, 38(3):240-248.
[12] 安娟, 红华. 2型糖尿病非增殖期黄斑水肿患者眼球后动脉血流动力学的超声评价[J]. 临床超声医学杂志, 2020, 22(1):13-16.
[13] 熊淑敏, 刘志兴, 陈莉. CDFI检测视网膜静脉阻塞及抗VEGF治疗前后眼血流动力学变化[J]. 南昌大学学报(医学版), 2020, 60(1):31-35, 40.
[14] 倪天宇, 李淑珍, 郭龙, 等. 激光光凝治疗缺血型视网膜分支静脉阻塞继发黄斑水肿的回顾性研究[J]. 内蒙古医学杂志, 2021, 53(8):970-972.
[15] 杜红彦, 王蓉, 李建良, 等. 活血明目汤联合雷珠单抗治疗非缺血型视网膜分支静脉阻塞继发黄斑水肿的临床研究[J]. 中国中医急症, 2020, 29(8):1381-1383, 1399.
[16] 彭立, 张小花, 劳娜, 等. 康柏西普与雷珠单抗治疗视网膜静脉阻塞继发黄斑水肿的Meta分析[J]. 国际眼科杂志, 2020, 20(3):455-463.
[17] 董照阳, 胡欣欣, 胡天明, 等. 阿柏西普和雷珠单抗治疗视网膜分支静脉阻塞继发黄斑水肿患者的临床疗效对比[J]. 临床眼科杂志, 2022, 30(2):115-118.
[18] 周瑞, 陈娟, 林思勇. 视网膜分支静脉阻塞继发黄斑水肿玻璃体注射雷珠单抗不同治疗方案的疗效对比[J]. 眼科, 2020, 29(1):63-67.
[19] 马丽琴. 雷珠单抗在眼部新生血管性疾病中的应用[J]. 中国药物与临床, 2020, 20(9):1479-1481.

彩色多普勒超声参数与BRVO合并ME患者病情程度、疗效的关系

The Relationship between Color Doppler Ultrasound Parameters and Disease Severity and Curative Effect in Patients with BRVO Combined with ME

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	赵桂桂, 刘俊霞, 朱方乔. 彩色多普勒超声在诊断新生儿缺氧缺血性脑病中的应用[J]. 影像科学与光化学, 2023, 41(1): 182-186.
[2]	刘海宁, 赵国栋, 齐海英. 孕早期UVC血流频谱参数联合孕中期四维彩超诊断心脏发育畸形的研究[J]. 影像科学与光化学, 2022, 40(6): 1359-1363.
[3]	程明艳, 姜浩, 孙亚男, 王艳春, 杨涛, 梅艳芳, 杜建文, 王晶华. HR-HPV基因联合TV-CDFI在宫颈癌筛查及诊断中的应用[J]. 影像科学与光化学, 2022, 40(6): 1481-1485.
[4]	计玉芳, 周键, 徐卫华, 徐敏, 朱峰. 不同影像学方法诊断乳腺癌的差异分析[J]. 影像科学与光化学, 2022, 40(5): 1015-1018.
[5]	王佳, 李晓天, 宋昊. 利伐沙班联合尿激酶对LEDVT的治疗效果及超声参数的影响[J]. 影像科学与光化学, 2022, 40(5): 1164-1168.
[6]	徐利, 陈友英. MCTSI、cf-DNA/NETs、D-二聚体与急性胰腺炎患者预后的相关性[J]. 影像科学与光化学, 2022, 40(4): 854-858.
[7]	周利, 宣之东, 李秀娟. 超声联合CA125、HE4检测对卵巢性索间质肿瘤的诊断分析[J]. 影像科学与光化学, 2022, 40(3): 545-549.
[8]	曾小芬, 李娜, 彭微玲. CDFI参数及超声评分诊断宫腔粘连的研究[J]. 影像科学与光化学, 2022, 40(2): 248-252.
[9]	邓奎品, 刘铁军, 郑英杰, 黄冬, 黄广苏. 磁敏感成像定量参数与帕金森病情程度及预后的关系[J]. 影像科学与光化学, 2022, 40(2): 258-262.
[10]	李朝喜, 温德惠, 陆海永, 刘伟亮. 不同超声技术及TI-RADS在甲状腺癌淋巴结转移中的应用效果[J]. 影像科学与光化学, 2022, 40(2): 335-338.
[11]	李春, 孙艳芳, 杨一, 王会敏, 周思. Holter辅助CDFI预测胎儿宫内窘迫的研究[J]. 影像科学与光化学, 2022, 40(2): 367-371.
[12]	肖旭, 赵淑霞, 黄立. 彩超联合人绒毛膜促性腺激素β诊断早期宫外孕的研究[J]. 影像科学与光化学, 2022, 40(1): 48-52.
[13]	武艳娇, 申海龙, 翟江, 冯金凤, 陈宝霞. 心脏彩超对AECOPD并发肺栓塞的评估价值[J]. 影像科学与光化学, 2022, 40(1): 109-113.
[14]	赵轶敏, 王亚萍. 彩色多普勒超声在浅表软组织肿块诊断中的应用分析[J]. 影像科学与光化学, 2022, 40(1): 161-164.
[15]	王玲玲, 曲海新. CDFI诊断胆道闭锁患儿的血流动力学参数特征及其价值[J]. 影像科学与光化学, 2021, 39(6): 888-891.