C70富勒醇对小鼠心脏毒性的研究

doi:10.7517/j.issn.1674-0475.180105

影像科学与光化学 ›› 2018, Vol. 36 ›› Issue (4): 324-330.DOI: 10.7517/j.issn.1674-0475.180105

C₇₀富勒醇对小鼠心脏毒性的研究

郭君^1,2, 周悦^2,3, 杨冬芝¹, 甄明明^2,3, 许辉², 王春儒^2,3

1. 徐州医科大学新药研究与临床药学重点实验室, 江苏徐州 221004;
2. 中国科学院化学研究所分子纳米结构与纳米技术院重点实验室, 北京 100190;
3. 中国科学院大学, 北京 100049

收稿日期:2018-01-18 修回日期:2018-03-02 出版日期:2018-07-15 发布日期:2018-07-15
通讯作者: 杨冬芝, 甄明明, 王春儒
基金资助:
国家重大科研装备项目（ZDYZ2015-2）资助

Cardiac Toxicity Study of C₇₀ Fullerenol Nanoparticles in Mice

GUO Jun^1,2, ZHOU Yue^2,3, YANG Dongzhi¹, ZHEN Mingming^2,3, XU Hui², WANG Chunru^2,3

1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, P. R. China;
2. Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China;
3. University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Received:2018-01-18 Revised:2018-03-02 Online:2018-07-15 Published:2018-07-15

摘要/Abstract

摘要： 研究C₇₀富勒醇（简写为C₇₀-OH）在常规治疗剂量下对小鼠心脏功能的影响。通过对小鼠行为学的观察和对心脏系数、血生化指标、心脏组织病理学和组织透射等的检测，结果显示常用的小分子血管阻断剂康普瑞汀磷酸二钠（CA4P）对心肌有明显损伤，而C₇₀-OH未表现出明显的心脏毒性。

关键词: C₇₀富勒醇, 病理学变化, 组织透射, 心脏毒性

Abstract: The cardiac effect of C₇₀ fullerenol nanoparticles (C₇₀-OH NPs) was studied in mice. After treated with the C₇₀-OH fullerene of normal therapeutic dose, behavioral observation, cardiac coefficient, blood biochemical changes, pathological changes and tissue transmission of mice were detected. The results showed that the commonly used small molecule vascular blocker combretastatin disodium phosphate (CA4P) significantly damaged the myocardium, while C₇₀-OH did not show significant cardiotoxicity.

Key words: C₇₀ fullerenol, pathological changes, tissue transmission, cardiac toxicity

郭君, 周悦, 杨冬芝, 甄明明, 许辉, 王春儒. C₇₀富勒醇对小鼠心脏毒性的研究[J]. 影像科学与光化学, 2018, 36(4): 324-330.

GUO Jun, ZHOU Yue, YANG Dongzhi, ZHEN Mingming, XU Hui, WANG Chunru. Cardiac Toxicity Study of C₇₀ Fullerenol Nanoparticles in Mice[J]. Imaging Science and Photochemistry, 2018, 36(4): 324-330.

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C₇₀富勒醇对小鼠心脏毒性的研究

Cardiac Toxicity Study of C₇₀ Fullerenol Nanoparticles in Mice

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