聚乙二醇功能化程度对纳米金壳夹心二氧化硅载药量及稳定性影响研究

doi:10.7517/j.issn.1674-0475.2011.03.212

影像科学与光化学 ›› 2011, Vol. 29 ›› Issue (3): 212-221.DOI: 10.7517/j.issn.1674-0475.2011.03.212

聚乙二醇功能化程度对纳米金壳夹心二氧化硅载药量及稳定性影响研究

陈帅娜¹, 刘惠玉², 陈东², 吴小莉², 唐芳琼², 杨文智¹

1. 河北大学药学院, 河北保定071002;
2. 中国科学院理化技术研究所纳米材料可控制备与应用研究室, 北京100190

收稿日期:2011-03-08 修回日期:2011-04-12 出版日期:2011-05-23 发布日期:2011-05-23
通讯作者: 唐芳琼,研究员,E-mail:tangfq@mail.ipc.ac.cn;杨文智,副教授,E-mail:wenzhi_yang@sina.com.
基金资助:
自然科学基金青年基金(30800258,30900348,81000667);自然科学基金面上基金(20873171)

The Influence of PEG Grafting Level on the Drug Loading Capacity and Stability of Gold Nanoshells on Silica Nanorattles

CHEN Shuai-na¹, LIU Hui-yu², CHEN Dong², WU Xiao-li², TANG Fang-qiong², YANG Wen-zhi¹

1. College of Pharmacy, Hebei University, Baoding 071002, Hebei, P. R. China;
2. Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Received:2011-03-08 Revised:2011-04-12 Online:2011-05-23 Published:2011-05-23

摘要/Abstract

摘要： 本文系统研究了不同聚乙二醇(PEG)功能化程度对纳米金壳夹心二氧化硅(GSNs)载药量及稳定性的影响.透射电子显微镜(TEM)观察结果表明,GSNs表面经修饰分子量为5 KDa的α-甲氧基-ω-巯基聚乙二醇(mPEG-SH)分子后,PEG分子层平均厚度约为4 nm;随PEG化程度增加,GSNs聚集沉降速度改善,稳定性提高,久置后(35 d)稳定性良好;电感耦合等离子体发射光谱(ICP-OES)测试表明,当PEG与Au反应摩尔比为0.24时,PEG分子层在金壳表面接近饱和;不同PEG化程度对GSNs载药量基本无影响.本研究可为优化无机纳米材料表面PEG修饰过程,发展无机纳米载体材料体内应用提供理论依据.

关键词: 聚乙二醇, 纳米金壳夹心二氧化硅, 稳定性, 载药量

Abstract: In this paper,we grafted various amounts of polyethylene glycol(PEG) onto the surface of gold nanoshells on silica nanorattles(GSNs) and investigated the effects of grafting level about drug loading capacity and stability of GSNs.The results showed that the average thickness of GSNs increased about 4 nm after PEGylation.With the increase of PEGylation,the sedimentation rate of GSNs decreased gradually and the stability increased,and GSNs keeps good stability after standing 35 days.Inductively coupled plasma atomic emission spectrometry(ICP-OES) tests show that it will reach saturation point of PEGylation when the molar ratio of PEG and Au reaches nearly 0.24.In addition,it has no influence on drug loading capacity about different PEGylation processes.The results of this study will provide an important theoretical basis for the optimization the PEGlyation on the surface of inorganic nanomaterials and for the development of inorganic nano-carrier materials in vivo applications.

Key words: polyethylene glycol, gold nanoshells on silica nanorattles, stability, drug loading capacity

中图分类号:

陈帅娜, 刘惠玉, 陈东, 吴小莉, 唐芳琼, 杨文智. 聚乙二醇功能化程度对纳米金壳夹心二氧化硅载药量及稳定性影响研究[J]. 影像科学与光化学, 2011, 29(3): 212-221.

CHEN Shuai-na, LIU Hui-yu, CHEN Dong, WU Xiao-li, TANG Fang-qiong, YANG Wen-zhi. The Influence of PEG Grafting Level on the Drug Loading Capacity and Stability of Gold Nanoshells on Silica Nanorattles[J]. Imaging Science and Photochemistry, 2011, 29(3): 212-221.

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聚乙二醇功能化程度对纳米金壳夹心二氧化硅载药量及稳定性影响研究

The Influence of PEG Grafting Level on the Drug Loading Capacity and Stability of Gold Nanoshells on Silica Nanorattles

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