影像科学与光化学 ›› 2016, Vol. 34 ›› Issue (5): 426-434.DOI: 10.7517/j.issn.1674-0475.2016.05.426

• 论文 • 上一篇    下一篇

两性聚合物光敏剂的合成及性能

骆司航, 赵春常   

  1. 华东理工大学 化学与分子工程学院 精细化工研究所, 上海 200237
  • 收稿日期:2016-07-20 修回日期:2016-08-08 出版日期:2016-09-15 发布日期:2016-09-15
  • 通讯作者: 赵春常

Synthesis and Evaluation of an Amphiphilic Polymer-based PDT Photosensitizer

LUO Sihang, ZHAO Chunchang   

  1. Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, P. R. China
  • Received:2016-07-20 Revised:2016-08-08 Online:2016-09-15 Published:2016-09-15

摘要:

本文设计合成了一种用于光动力治疗的聚合物光敏剂PDPA-AMA-BOD。研究表明,在pH中性时,聚合物自组装形成胶束,疏水端的光敏剂被包裹在疏水内腔中,处于局部高浓度聚集态,引发homo-FRET效应,单重态氧效率大幅降低;而在弱酸性条件下,由于疏水端的氨基功能团质子化,胶束形态被破坏,聚合物分子均匀分散水中,降低了光敏剂的自粹灭,PDPA-AMA-BOD具有较高的单重态氧效率。PDPA-AMA-BOD的pH响应特性赋予其在肿瘤细胞弱酸性环境中光动力靶向治疗肿瘤的能力。

关键词: 两性聚合物, 光敏剂, 胶束, 单重态氧, 光动力学治疗

Abstract:

We designed and synthesized anamphiphilic polymer-based PDT photosensitizer PDPA-AMA-BOD. Experimental results demonstrated that PDPA-AMA-BOD could self-assemble into micelles in neutral aqueous environment and thus enabled the BODIPY photosensitizer trapped within the hydrophobic interior, which induced a high local concentration of BODIPY. As such, the efficiency of 1O2 generation was reduced by homo-FRET effect. In contrast, the protonation of amino sites attached to the hydrophobic end of PDPA-AMA-BOD resulted in the polymer well-dispersing in acidic aqueous solutions. As a consequence, concentration induced inhibition of 1O2 production was abolished. In this way, PDPA-AMA-BOD showed the acidity-controlled production of 1O2, suggesting the potential application as a selective PDT photosensitizer towards acidic tumor microenvironment.

Key words: amphiphilic polymer, photosensitizer, micelle, 1O2, photodynamic therapy