双光子聚合技术在组织工程学方面的研究进展

doi:10.7517/j.issn.1674-0475.2017.04.005

摘要/Abstract

摘要：

细胞外基质（ECM）是分布在细胞表面或细胞之间的大分子，具有复杂的网络结构，通过与细胞的相互作用调节着细胞的生长、增殖和分化，然而截止到目前这种复杂的调节作用还没有被完全理解。新兴的组织工程学通过体外构筑ECM来培养组织或器官，能够系统、深入的研究细胞与ECM之间的相互作用，进而为再生医学的发展奠定基础。双光子聚合技术具有穿透性好、空间选择性高、对生物组织损伤小等特点，是体外构筑ECM的理想方案。本文介绍了双光子吸收和双光子聚合的基本原理，梳理了水溶性双光子聚合光敏剂的研究概况，综述了光聚合水凝胶材料的研究进展并对后续研究进行了展望。

关键词: 双光子聚合, 组织工程, 水溶性光敏剂, 水凝胶

Abstract:

The natural extracellular matrix (ECM) is a collection of extracellular macromolecules distributed on the cell surfaces or in the intercellular spaces, having a complex grid structure. Through the intimate interaction with cells, it regulates cell growth, proliferation and differentiation. Up to now, the cell-ECM interaction has not been fully understood. The new-emerging tissue engineering involves the construction of a scaffold (ECM in vitro) for the formation of new tissue or organ, which is beneficial to deeply understand the cell-ECM interaction and further lay the foundation for the development of regenerative medicine. Two-photon polymerization (2PP) is an ideal way to construct ECM in vitro due to its advantages of large penetration depth, high spatial selectivity and little damage to biological tissue. In this review, the principles of two-photon absorption and 2PP are introduced firstly. The development of water-soluble photosensitizers and photo-polymerizable hydrogels for tissue engineering are mainly summarized. Finally, the perspective of 2PP technology for tissue engineering is also proposed.

Key words: two-photon polymerization(2PP), tissue engineering, water-soluble photosensitizer, hydrogels

黄星, 刘源, 王潇朴, 赵榆霞. 双光子聚合技术在组织工程学方面的研究进展[J]. 影像科学与光化学, 2017, 35(4): 396-412.

HUANG Xing, LIU Yuan, WANG Xiaopu, ZHAO Yuxia. Progress of Two-photon Polymerization Technology in Tissue Engineering[J]. Imaging Science and Photochemistry, 2017, 35(4): 396-412.

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