基于纸基的荧光碳量子点传感器的可视化检测研究进展

doi:10.7517/j.issn.1674-0475.180404

摘要/Abstract

摘要： 碳量子点作为一种新型的纳米材料，其独特的荧光性能使其在物质检测领域得到了越来越多的关注。利用碳量子点与物质反应导致荧光强度发生变化的特性，可将其应用于可视化检测，检测方法分为荧光猝灭型和荧光恢复型。基于纸基的荧光传感器与基于液相反应的荧光检测相比，其快速、现场和可视化的特点更加突出，因此有着更为广泛的应用。本文针对碳量子点的荧光特性、可视化荧光检测、纸基传感器的研究现状，并结合本课题组相关研究进展进行论述，以期为今后纸基碳量子点荧光传感器的研究和应用提供参考。

关键词: 碳量子点, 荧光, 可视化检测, 纸基

Abstract: Carbon quantum dots (CQDs), as a new class of nanomeaterials, have exhibited broad appeal for chemical inspections according to their peculiar fluorescent properties. When interacting with detected molecules, their tunable fluorescence intensity can be applied in visual detection which includes FQ-type (fluorescent quenching) and FR-type (fluorescent recovery) detection. Compared with aqueous fluorescent sensors, paper-based devices are more extensively utilized in the field of substance inspections concerning their superiorities in portability, fast-response, on-site examination and visualization. Herein, we review recent research status and progress in the field of CQDs to provide a future perspective incorporating fluorescent properties of CQDs, current visual fluorescent inspections and paper-based sensors.

Key words: carbon quantum dots, fluorescence, visual detection, paper base

高文宇, 周奕华, 滕潇, 吴丽辉, 曹晟. 基于纸基的荧光碳量子点传感器的可视化检测研究进展[J]. 影像科学与光化学, 2018, 36(4): 367-379.

GAO Wenyu, ZHOU Yihua, TENG Xiao, WU Lihui, CAO Sheng. Research Progress of Paper-based Fluorescent Sensor on Carbon Quantum Dots for Visual Detection[J]. Imaging Science and Photochemistry, 2018, 36(4): 367-379.

参考文献

[1] Ploehn H J, Gu Y L, Xu X Y, Raker K, Gearheart L, Ray R, Scrivens W A. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments[J]. Journal of the American Chemical Society, 2004, 126(40):12736-12737.
[2] Sun Y P, Zhou B, Lin Y,Wang W, Fernando K A, Pathak P, Meziani M J, Harruff B A, Wang X, Luo P G, Yang H, Kose M E, Chen B, Veca L M, Xie S Y. Quantum-sized carbon dots for bright and colorful photoluminescence[J]. Journal of the American Chemical Society, 2006, 128(24):7756-7757.
[3] Lim S Y, Shen W, Gao Z. Carbon quantum dots and their applications[J]. Chemical Society Reviews, 2015, 44(1):362-381.
[4] Qian J, Hua M J, Wang C Q, Wang K, Liu Q, Hao N, Wang K. Fabrication of l-cysteine-capped CdTe quantum dots based ratiometric fluorescence nanosensor for onsite visual determination of trace TNT explosive[J]. Analytica Chimica Acta, 2016, 946:80-87.
[5] Wang Y F, Hu A G. Carbon quantum dots:synthesis, properties and applications[J]. Journal of Materials Chemistry C, 2015, 2(34):6921-6939.
[6] Chen X C, Yu S M, Yang L, Wang J P, Jiang C L. Fluorescence and visual detection of fluoride ion using photoluminescent graphene oxide paper sensor[J]. Nanoscale, 2016, 8(28):13669-13677.
[7] Zhang K, Zhou H B, Mei Q S, Wang S H, Guan G J, Liu R Y, Zhang J, Zhang Z P. Instant visual detection of trinitrotoluene particulates on various surfaces by ratiometric fluorescence of dual-emission quantum dots hybrid[J]. Journal of the American Chemical, 2011, 133(22):8424-8427.
[8] Liu X, Yang Y, Xing X X, Wang Y D. Grey level replaces fluorescent intensity:Fluorescent paper sensor based on ZnO nanoparticles for quantitative detection of Cu²⁺ without photoluminescence spectrometer[J]. Sensors and Actuators B Chemical, 2018, 255(2):2356-2366.
[9] Scordo G, Moscone D, Palleschi G, Arduini F. A reagent-free paper-based sensor embedded in a 3D printing device for cholinesterase activity measurement in serum[J]. Sensors and Actuators B:Chemical, 2018, 258(1):1015-1021.
[10] Wang X R, Li B W, You H Y, Chen L X. An ion imprinted polymers grafted paper-based fluorescent sensor based on quantum dots for detection of Cu²⁺ ions[J]. Chinese Journal of Analytical Chemistry, 2015, 43(10):1499-1504.
[11] Baker S N, Baker G A. Luminescent carbon nanodots:Emergent nanolights[J]. Angewandte Chemie International Edition, 2010, 49(38):6726-6744.
[12] Gao J, Zhu M M, Huang H, Liu Y, Kang Z H. Advances, challenges and promises of carbon dots[J]. Inorganic Chemistry Frontiers, 2017, 4(12):1963-1986.
[13] Zhu S J, Song Y B, Zhao X H, Shao J R, Zhang J H, Yang B. The photohnninescence mechanism in carbon dot (graphene quantum dots, carbon nanodots, and polymer dots):current state and future perspective[J]. Nano Research, 2015, 8(2):355-381.
[14] Zhang Z H, Sun W H, Wu P Y. Highly photoluminescent carbon dots derived from egg white:facile and green synthesis, photoluminescence properties, and multiple applications[J]. ACS Sustainable Chemistry and Engineering, 2015, 3(7):1412-1418.
[15] Qiao Z A, Wang Y, Gao Y, Li H, Dai T, Liu Y, Huo Q. Commercially activated carbon as the source for producing multicolor photoluminescent carbon dots by chemical oxidation[J]. Chemical Communications, 2010, 46(46):8812-8814.
[16] Zhao Q L, Zhang Z L, Huang B H, Peng J, Zhang M, Pang D W. Facile preparation of low cytotoxicity fluorescent carbon nanocrystals by electrooxidation of graphite[J].Chemical Communications, 2008, 41(41):5116-5118.
[17] 邓亚峰,周奕华,钱俊,罗妍,吴丽辉. 基于上转换发光的碳量子点制备及应用研究[J]. 影像科学与光化学,2017,35(6):884-893. Deng Y F, Zhou Y H, Qian J, Luo Y, Wu L H. Preparation and application of carbon quantum dots based on up conversion photoluminescence[J]. Imaging Science and Photochemistry, 2017, 35(5):884-893.
[18] Tao H, Yang K, Ma Z, Wan J, Zhang Y, Kang Z, Liu Z. In vivo NIR fluorescence imaging, biodistribution, and toxicology of photoluminescent carbon dots produced from carbon nanotubes and graphite[J]. Small, 2012, 8(2), 281-290.
[19] Li H T, He X D, Kang Z H, Huang H, Liu Y, Liu J L, Lian S Y, Tsang C H A, Yang X B, Lee S T. Water-soluble fluorescent carbon quantum dots and photocatalyst design[J]. Angewandte Chemie International Edition, 2010, 49(26):4430-4434.
[20] Hu S L, Niu K Y, Sun J, Yang J, Zhao N Q, Du X W. One-step synthesis of fluorescent carbon nanoparticles by laser irradiation[J]. Journal of Materials Chemistry, 2009, 19(4):484-488.
[21] Fang Y, Guo S, Li D, Zhu C Z, Ren W, Dong S J, Wang E K. Easy synthesis and imaging applications of cross-linked green fluorescent hollow carbon nanoparticles[J]. ACS Nano, 2011, 6(1):400-409.
[22] Bao L, Zhang Z L, Tian Z Q, Zhang L, Lin C, Liu Y, Qi B P, Pang D W. Electrochemical tuning of luminescent carbon nanodots:from preparation to luminescence mechanism[J]. Advanced Materials, 2011, 23(48):5801-5806.
[23] Hu S L, Trinchi A, Atkin P, Cole I. Tunable photoluminescence across the entire visible spectrum from carbon dots excited by white light[J]. Angewandte Chemie International Edition, 2015, 54(10):2970-2974.
[24] Liu H P, Ye T, Mao C D. Fluorescent Carbon nanoparticles derived from candle soot[J]. Angewandte Chemie International Edition, 2007, 46(34):6473-6475.
[25] Ding H, Yu S B, Wei J S, Xiong H M. Full-color light-emitting carbon dots with a surface-state-controlled luminescence mechanism[J]. ACS Nano, 2015, 10(1):484-491.
[26] Kasha M. Collisional perturbation of spin-orbital coupling and the mechanism of fluorescence quenching. a visual demonstration of the perturbation[J]. Journal of Chemical Physics, 1952, 20(1):71-74.
[27] El-sayed M A. Triplet state. Its radiative and nonradiative properties[J]. Accounts of Chemical Research, 1968, 1(1):8-16.
[28] Koziar J C. Cowan D O. Photochemical heavy-atom effects[J].Accounts of Chemical Research, 1978, 11(9):334-341.
[29] Gonçalves H M R, Duarte A J, Silva J C G E D. Optical fiber sensor for Hg(Ⅱ) based on carbon dots[J]. Biosensors and Bioelectronics, 2010, 26(4):1302-1306.
[30] Barman S, Sadhukhan M. Facile bulk production of highly blue fluorescent graphitic carbon nitride quantum dots and their application as highly selective and sensitive sensors for the detection of mercuric and iodide ions in aqueous media[J]. Journal of Materials Chemistry, 2012, 22(41):21832-21837.
[31] Gao X H, Du C, Zhuang Z H, Chen W. Carbon quantum dot-based nanoprobes for metal ion detection[J]. Journal of Materials Chemistry C, 2016, 4(29):3898-3904.
[32] Mohapatra S, Sahu S, Sinha N, Bhutia S K. Synthesis of a carbon-dot-based photoluminescent probe for selective and ultrasensitive detection of Hg²⁺ in water and living cells[J]. Analyst, 2015, 140(4):1221-1228.
[33] Yu J, Xu C X, Tian Z S, Lin Y, Shi Z L. Facilely synthesized N-doped carbon quantum dots with high fluorescent yield for sensing Fe³⁺[J]. New Journal of Chemistry, 2016, 40(3):2083-2088.
[34] Xu Q, Pu P, Zhao J G, Dong C B, Gao C, Chen Y S, Chen J R, Liu Y, Zhou H J. Preparation of highly photoluminescent sulfur-doped carbon dots for Fe(Ⅲ) detection[J]. Journal of Materials Chemistry A, 2015, 3(3):542-546.
[35] Xu P P, Wang C F, Sun D, Chen Y J, Zhuo K L. Ionic liquid as a precursor to synthesize nitrogen-and sulfur-co-doped carbon dots for detection of copper(Ⅱ) ions[J]. Chemical Research in Chinese Universities, 2015, 31:730-735.
[36] Shi L, Li Y, Li X, Zhao B, Wen X, Zhang G, Dong C, Shuang S. Controllable synthesis of green and blue fluorescent carbon nanodots for pH and Cu(²⁺) sensing in living cells[J]. Biosensors and Bioelectronics, 2015, 77:598-602.
[37] Wang Y, Wu W T, Wu M B, Sun H D, Xie H, Hu C, Wang X N, Wu X Y, Qiu J S. Yellow-visual fluorescent carbon quantum dots from petroleum coke for the efficient detection of Cu²⁺ ions[J]. New Carbon Materials, 2016, 104(6):550-559.
[38] Wang X, Shen X, Li B Z, Jiang G Y, Zhou X M, Jiang H J. One-step facile synthesis of novel β-amino alcohol functionalized carbon dots for the fabrication of a selective copper ion sensing interface based on the biuret reaction[J]. RSC Advances, 2016, 6(22):18326-18332.
[39] Gedda G, Lee C Y, Lin Y C, Wu H F. Green synthesis of carbon dots from prawn shells for highly selective and sensitive detection of copper ions[J]. Sensors and Actuators B Chemical, 2016, 224:396-403.
[40] Niu X Q, Liu G S, Li L Y, Fu Z, Xu H, Cui F L. Green and economical synthesis of nitrogen-doped carbon dots from vegetables for sensing and imaging applications[J]. RSC Advances, 2015, 5(115):95223-95229.
[41] Salinas-Castillo A, Morales D P, Lapresta-Fernández A, Ariza-Avidad M, Castillo E, Martínez-Olmos A, Palma A J, Palma L F, Capitan-Vallvey. Evaluation of a reconfigurable portable instrument for copper determination based on luminescent carbon dots[J]. Analytical and Bioanalytical Chemistry, 2016, 408(11):
[42] Lin Y Q, Wang C, Li L B, Wang H, Liu K Y, Wang K Q, Li B. Tunable fluorescent silica-coated carbon dots:a synergistic effect for enhancing the fluorescence sensing of extracellular Cu²⁺ in rat brain[J]. ACS Applied Materials and Interfaces, 2015, 7(49):27262-27270.
[43] Wang Y H, Zhang C, Chen X C, Yang B, Yang L, Jiang C L, Zhang Z P. Ratiometric fluorescent paper sensor utilizing hybrid carbon dots-quantum dots for the visual determination of copper ions[J]. Nanoscale, 2016, 8(11):5977-5984.
[44] Sun X H, Zhou T T, Cui H L, Gao L J, Wang Z. Detection of trace cadmium ion based on carbon quantum dots as fluorescence probe[J]. Chinese Journal of Analysis Laboratory, 2015, 7:788-790.
[45] Liang S S, Qi L, Zhang R L, Jin M, Zhang Z Q. Ratiometric fluorescence biosensor based on CdTe quantum and carbon dots for double strand DNA detection[J]. Sensors and Actuators B Chemical, 2017, 244:585-590.
[46] Yuan Y S, Zhao X, Qiao M, Zhu J H, Liu S P, Yang J D, Hu X L. Determination of sunset yellow in soft drinks based on fluorescence quenching of carbon dots[J]. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy, 2016, 167:106-110.
[47] Mishra R K, Pulidindi I N, Kabha E, Gedanken A. In situ formation of carbon dots aids ampicillin sensing[J]. Analytical Methods, 2016, 8(11):2441-2447.
[48] Wang J B, Qian X H. Two regioisomeric and exclusively selective Hg(Ⅱ) sensor molecules composed of a naphthalimide fluorophore and an o-phenylenediamine derived triamide receptor[J]. Chemical Communications, 2006, (1):109-111.
[49] Huang W, Song C X, He C, Lv G J, Hu X Y, Zhu X, Duan C Y. Recognition preference of rhodamine-thiospirolactams for mercury (Ⅱ) in aqueous solution[J]. Inorganic Chemistry, 2009, 48(12):5061-5072.
[50] Zheng Y S, Hu Y J. Chiral recognition based on enantioselectively aggregation-induced emission[J]. The Journal of Organic Chemistry, 2009, 74(15):5660-5663.
[51] Das R K, Mohapatra S. Highly luminescent, heteroatom-doped carbon quantum dots for ultrasensitive sensing of glucosamine and targeted imaging of liver cancer cells[J]. Journal of Materials Chemistry B, 2017, 5(11):2190-2197.
[52] Hu Y L, Zhang L, Geng X, Ge J, Liu H F, Li Z H. A rapid and sensitive turn-on fluorescent probe for ascorbic acid detection based on carbon dots-MnO₂ nanocomposites[J]. Analytical Methods, 2017, 9:5653-5658.
[53] Lei C H, Zhao X E, Jiao S L, He L, Li Y, Zhu S Y, You J M. A turn-on fluorescent sensor for the detection of melamine based on the anti-quenching ability of Hg²⁺ to carbon nanodots[J]. Analytical Methods, 2016, 8(22):4438-4444.
[54] He D G, Yang X X, He X X, Wang K M, Yang X, He X, Zou Z. A sensitive turn-on fluorescent probe for intracellular imaging of glutathione using single-layer MnO₂ nanosheet-quenched fluorescent carbon quantum dots[J]. Chemical Communications, 2015, 51(79):14764-14767.
[55] Shi Y P, Pan Y, Zhang H, Zhang Z M, Li M J, Yi C Q, Yang M S. A dual-mode nanosensor based on carbon quantum dots and gold nanoparticles for discriminative detection of glutathione in human plasma[J]. Biosensors and Bioelectronics, 2014, 56(3):39-45.
[56] Tian X K, Peng H, Li Y. Highly sensitive and selective paper sensor based on carbon quantum dots for visual detection of TNT residues in groundwater[J]. Sensors and Actuators B Chemical, 2017, 243:1002-1009.
[57] Liu C, Ning D H, Zhang C, Liu Z J, Zhang R L, Zhao J, Zhao T T, Liu B H, Zhang Z P. Dual-colored carbon dot ratiometric fluorescent test paper based on a specific spectral energy transfer for semiquantitative assay of copper ions[J]. ACS Applied Materials and Interfaces, 2017, 9(22):18897-18903.
[58] 周奕华,吴丽辉,钱俊,罗妍,邓亚峰. 基于石墨烯量子点的全印刷纸质生物传感器[J]. 南京工业大学学报(自然科学版), 2018, 40(2):137-144. Zhou Y H, Wu L H, Qian J, Luo Y, Deng Y F. All-printed paper biosensor based on graphene quantum dots[J]. Journal of Nanjing University of Technology (Natural Science Edition), 2018, 40(2):137-144.