• 综述与论文 •

超声造影参数对宫颈癌新辅助化疗疗效的评估价值

1. 鄂东医疗集团 黄石市妇幼保健院 超声科, 湖北 黄石 435003
• 收稿日期:2019-07-05 出版日期:2020-01-15 发布日期:2020-01-15

The Value of Contrast-enhanced Ultrasound Parameters in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Cervical Cancer

JI Yamei, SHEN Cui

1. Department of Ultrasound, Huangshi Maternity and Children's Health Hospital, Edong Healthcare Group, Huangshi 435003, Hubei, P. R. China
• Received:2019-07-05 Online:2020-01-15 Published:2020-01-15

Abstract: The value of contrast-enhanced ultrasound parameters in evaluating the efficacy of neoadjuvant chemotherapy for cervical cancer was analyzed in this study. 200 patients with cervical cancer undergoing the neoadjuvant chemotherapy from March 2016 to March 2018 in our hospital were selected as the subjects of this study, all patients were given paclitaxel + cisplatin (TP) regimen chemotherapy and the contrast-enhanced ultrasound, the value of contrast-enhanced ultrasound parameters[initial enhancement time (AT), time to peak (TTP), base intensity (BI), peak intensity (PI), enhancement intensity (EI)] in evaluating the efficacy of neoadjuvant chemotherapy were analyzed. The results showed that there were 12 cases of complete remission (CR), 136 cases of partial remission (PR), 36 cases of stable disease (SD), 16 cases of deterioration (PD) and 148 cases of chemotherapy effective, the effective rate was 74.00%. The comparison of the BI and EI between the effective patients and the ineffective patients before and after chemotherapy, the comparison of the AT, TTP, PI in the ineffective patients before and after chemotherapy, the difference was not statistically significant (P>0.05), the AT and TTP after chemotherapy in the effective patients were significantly lower than those before chemotherapy, the PI after chemotherapy in the effective patients were significantly higher than those before chemotherapy, the AT and TTP after chemotherapy in the ineffective patients were significantly higher than those in the effective patients, the PI after chemotherapy in the ineffective patients were significantly lower than those in the effective patients, the AT and TTP decreased value, PI increased value were significantly higher than those in the ineffective group, the difference was statistically significant (P<0.05). The ROC curve analysis of the sensitivity, specificity, accuracy of evaluating the efficacy of neoadjuvant chemotherapy for cervical cancer showed that, the combination of the three methods were statistically significant higher than the three alone, the difference was statistically significant (P<0.05). This study confirms that, contrast-enhanced ultrasound parameters AT, TTP, PI are related to the efficacy of neoadjuvant chemotherapy for cervical cancer, and can be used as an index to evaluate the effectiveness of chemotherapy, and the combination of the three is more effective.