超声脐动脉S/D联合血清IGF-1和胆汁酸对新生儿窒息的临床诊断价值分析

doi:10.7517/issn.1674-0475.190715

影像科学与光化学 ›› 2020, Vol. 38 ›› Issue (1): 80-86.DOI: 10.7517/issn.1674-0475.190715

超声脐动脉S/D联合血清IGF-1和胆汁酸对新生儿窒息的临床诊断价值分析

董亚男, 庞远, 李海朋, 舒展, 肖秀娟

河北省唐山市协和医院, 河北唐山 063000

收稿日期:2019-07-24 出版日期:2020-01-15 发布日期:2020-01-15
基金资助:
河北省卫生和计划生育委员会科研基金项目（20160880）资助

Clinical Diagnostic Value of Ultrasound Umbilical Artery S/D Combined with Serum IGF-1 and Bile Acid in Neonatal Asphyxia

DONG Ya'nan, PANG Yuan, LI Haipeng, SHU Zhan, XIAO Xiujuan

Tangshan Union Medical College Hospital, Tangshan 063000, Hebei, P. R. China

Received:2019-07-24 Online:2020-01-15 Published:2020-01-15

摘要/Abstract

摘要： 本文通过观察新生窒息患儿和正常新生儿多普勒超声脐动脉血流S/D比值、血清胰岛素样生长因子（IGF-1）、胆汁酸（TBA）水平差异，探讨脐动脉血流S/D比值联合血清IGF-1和TBA在新生儿窒息中的诊断价值。实验结果表明，脐动脉血流S/D比值、血清IGF-1、TBA在新生儿窒息与正常新生儿、不同窒息程度患儿、伴新生儿缺血缺氧性脑病（HIE）的患儿中均有显著差异。多重线性回归结果表明脐动脉血流S/D比值、血清TBA、IGF-1与新生儿窒息评价指标Apgar评分存在密切关系。受试者工作特征曲线分析结果表明脐动脉血流S/D比值、血清IGF-1、TBA诊断新生儿窒息具有较高应用价值，且联合上述指标检测诊断价值更高。

关键词: S/D, IGF-1, 胆汁酸, 新生儿窒息

Abstract: By observing the difference of S/D ratio of umbilical artery blood flow, serum insulin-like growth factor (IGF-1) and bile acid (TBA) levels between neonates with asphyxia and normal neonates, the diagnostic value of S/D ratio of umbilical artery blood flow combined with serum IGF-1 and TBA in neonatal asphyxia was discussed. The results showed that the S/D ratio of pulse blood flow, serum IGF-1 and TBA were significantly different between neonatal asphyxia and normal 80 neonates, children with different degrees of asphyxia and neonatal ischemic-hypoxic encephalopathy (HIE). The results of multiple linear regression showed that umbilical artery blood flow S/D ratio, serum TBA, IGF-1 were closely related to the Apgar score of neonatal asphyxia evaluation index. The analysis of the receiver operating characteristic curve of the subjects showed that the S/D ratio of umbilical artery blood flow, serum IGF-1 and TBA had high application value in the diagnosis of neonatal asphyxia, and the combined detection of the above indicators had higher diagnostic value.

Key words: S/D, IGF-1, bile acid, neonatal asphyxia

董亚男, 庞远, 李海朋, 舒展, 肖秀娟. 超声脐动脉S/D联合血清IGF-1和胆汁酸对新生儿窒息的临床诊断价值分析[J]. 影像科学与光化学, 2020, 38(1): 80-86.

DONG Ya'nan, PANG Yuan, LI Haipeng, SHU Zhan, XIAO Xiujuan. Clinical Diagnostic Value of Ultrasound Umbilical Artery S/D Combined with Serum IGF-1 and Bile Acid in Neonatal Asphyxia[J]. Imaging Science and Photochemistry, 2020, 38(1): 80-86.

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超声脐动脉S/D联合血清IGF-1和胆汁酸对新生儿窒息的临床诊断价值分析

Clinical Diagnostic Value of Ultrasound Umbilical Artery S/D Combined with Serum IGF-1 and Bile Acid in Neonatal Asphyxia

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