Imaging Science and Photochemistry ›› 2020, Vol. 38 ›› Issue (4): 703-707.DOI: 10.7517/issn.1674-0475.200105

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Effects of Er: YAG Laser Combined with Budesonide on Male OSAHS

WANG Yanhui, LIANG Suozhu, WANG Jianshuang, YIN Huili   

  1. Second Division of Medical Department, The Fourth People's Hospital of Langfang, Langfang 065700, Hebei, P. R. China
  • Received:2020-01-13 Online:2020-07-15 Published:2020-07-15

Abstract: This paper intends to investigate the effect of Er:YAG laser combined with Budesonide spray on male obstructive sleep apnea hypopnea syndrome(OSAHS). 90 male patients with OSAHS were randomly divided into control group (Budesonide spray treatment, n=45) and observation group (Er:YAG laser combined with Budesonide spray treatment, n=45). The differences in apnea hypopnea index (AHI), apnea time, the lowest nighttime SpO2 and interleukin-6 (IL-6), tumor necrosis factor -α(TNF-α), nuclear factor κB (NF-κB), alveolar surface active protein-A (SP-A), alveolar surface active protein-D (SP-D), total testosterone(TT), luteinizing hormone (LH), follicle stimulating hormone (FSH)were compared between the two groups before and after treatment. The results showed that the total effective rate in the observation group was significantly higher than that in the control group (P<0.05). Compared with those before treatment, the AHI, maximum apnea time, the serum levels of IL-6,TNF-α, NF-κB, SP-A, SP-D in two groups were significantly decreased after treatment (P<0.05), while the lowest nighttime SpO2, the serum levels of TT, LH and FSH in two groups increased significantly (P<0.05). The improvement in the observation group was better than that in the control group (P< 0.05). The results indicate that Er:YAG laser combined with Budesonide spray is more effective than Budesonide spray alone in the treatment of mild OSAHS, which can not only improve the clinical symptoms, but also conduce to recovery of sex hormones and improvement of inflammatory response of the patients.

Key words: obstructive sleep apnea hypopnea syndrome, Er:YAG laser, Budesonide spray, sex hormone