IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1269-1273.DOI: 10.7517/issn.1674-0475.220307

• Review and Articles • Previous Articles     Next Articles

Correlation between CTP Whole-Cerebral Perfusion Imaging Parameters and Hcy and Its Diagnostic Value for Ischemic Stroke

WU Binbin, YU Yongqiang   

  1. Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, P. R. China
  • Received:2022-03-08 Published:2022-09-13

Abstract: This paper investigated the correlation between cerebral perfusion imaging parameters of CTP and homocysteine (Hcy) and its diagnostic value in ischemic stroke. 156 patients with suspected ischemic stroke were selected, 80 patients with confirmed ischemic stroke were selected as the study group, and 76 patients with non-ischemic stroke as the control group. All patients underwent CTP whole- cerebral perfusion imaging examination, and Hcy expression level was detected by enzyme-linked immunoassay (ELISA). The results showed that compared with the control group, the parameters of cerebral blood flow (CBF), cerebral blood volume (CBV) in the study group were decreased, while the parameters of mean transit time (MTT) and time to peak (TTP) were increased (P<0.05). In study group the CBF and CBV parameters were decreased, MTT, TTP parameters and Hcy expression levels were increased in severe patients compared with mild and moderate patients in the study group (P<0.05). Compared with the single diagnosis of CBF, CBV, MTT and TTP, the combined diagnosis of the four items had higher diagnostic value for ischemic stroke, the AUC was 0.876 (P<0.05). CTP whole-cerebral perfusion imaging has high application value in the diagnosis of ischemic stroke patients and is related to the Hcy index of patients, which can be used for the diagnosis of ischemic stroke.

Key words: CTP whole cerebral perfusion imaging, homocysteine, ischemic stroke