IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1133-1137.DOI: 10.7517/issn.1674-0475.220320

• Review and Articles • Previous Articles     Next Articles

Study of DECT Myocardial Perfusion Imaging Combined with Serum ANXA1 in the Diagnosis of Myocardial Infarction

LUO Wei1, ZHANG Jing1, LI Qian2   

  1. 1. Department of General Medicine, Tangshan Workers' Hospital, Tangshan 063000, Hebei, P. R. China;
    2. Department of Neurology, Tangshan Workers' Hospital, Tangshan 063000, Hebei, P. R. China
  • Received:2022-03-10 Published:2022-09-13

Abstract: This study investigated the value of dual-source dual-energy CT (DECT) myocardial perfusion imaging combined with serum annexin A1 (ANXA1) in the diagnosis of myocardial infarction. 100 patients with suspected myocardial infarction who underwent DECT myocardial perfusion were selected. All patients were examined with a German Siemens large-pitch dual-source dual-energy CT scanner, and the serum ANXA1 level was detected by an enzyme-linked immunosorbent (ELISA) kit. The coronary angiography and clinical data were used as the gold standard, 55 cases were diagnosed as myocardial infarction and 45 cases as non-myocardial infarction. The sensitivity and specificity of DECT for the diagnosis of myocardial infarction were 92.73% and 88.89%, respectively. The level of serum ANXA1 in patients with myocardial infarction was significantly lower than that in patients without myocardial infarction (t=6.582,P<0.001). The sensitivity and specificity of serum ANXA1 for the diagnosis of myocardial infarction were 92.73% and 68.89%, respectively. With the combined diagnosis based on serum ANXA1 level ≤ 1.92 ng/mL as a positive index or a positive DECT diagnosis result, the sensitivity and specificity of DECT combined with serum ANXA1 for the diagnosis of myocardial infarction were 99.47% and 61.24%, respectively. DECT combined with serum ANXA1 can effectively improve the diagnostic sensitivity of myocardial infarction, also could reduce the missed diagnosis rate, and has a high potential clinical value.

Key words: myocardial infarction, dual-source dual-energy CT, annexin A1, serological index, sensitivity, missed diagnosis rate