IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1274-1279.DOI: 10.7517/issn.1674-0475.220330

• Review and Articles • Previous Articles     Next Articles

Application of T1WI Signal Intensity of Globus Pallidus Combined with MRS Image in the Diagnosis of Neonatal HB

KANG Zhilei, DU Naiyi, LIU Zhaoyan, LI Yang, JIANG Lijie   

  1. Image Center of Hengshui People's Hospital, Hengshui 053000, Hebei, P. R. China
  • Received:2022-03-28 Published:2022-09-13

Abstract: This paper investigated the differential diagnostic value of globus pallidus T1-weighted image (T1WI) signal intensity combined with magnetic resonance spectroscopy (MRS) images for neonatal hyperbilirubinemia (HB) condition, and the correlation analysis with serum bilirubin (TsB) and transcutaneous bilirubin (TcB). 132 neonates with HB were selected, and according to the serum TsB level they were divided into mild, moderate and severe groups. Among them there were 42 cases of children with concomitant acute bilirubin encephalopathy, and 47 healthy neonates at the same time were selected as the control group. All neonates were performed magnetic resonance examination to obtain globus pallidus T1WI signal intensity and MRS image related indexes[N-ethylphthalate aspartate (NAA)/creatine complex (Cr), choline complex (Cho)/Cr, Cho/NAA]. The results showed that the T1WI signal intensity of the left and right globus pallidus, Cho/Cr, Cho/NAA in the severe group > moderate group > mild group > control group, and the NAA/Cr in the severe group < moderate group < mild group < control group (P<0.05). The T1WI signal intensity of the left and right globus pallidus in children with HB were negatively correlated with NAA/Cr and positively correlated with Cho/Cr and Cho/NAA (P<0.05). The area under the curve (AUC) of left globus pallidus T1WI signal intensity, right globus pallidus T1WI signal intensity, NAA/Cr, Cho/Cr, Cho/NAA combined diagnosis of neonatal HB was 0.901. The signal intensity of left and right globus pallidus T1WI, Cho/Cr, Cho/NAA were higher in children with concomitant acute bilirubin encephalopathy after treatment were higher than those of the control group, and the NAA/Cr were lower than those of the control group (P<0.05). It can be seen that the T1WI signal intensity of the globus pallidus combined with MRS images has high sensitivity and specificity in the diagnosis of HB in newborns, and the early detection can assist in the clinical prevention and treatment measures.

Key words: neonatal hyperbilirubinemia, T1WI signal intensity of globus pallidus, magnetic resonance spectroscopy imaging, transcutaneous bilirubin, total serum bilirubin