IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1164-1168.DOI: 10.7517/issn.1674-0475.220406

• Review and Articles • Previous Articles     Next Articles

Therapeutic Effect of Rivaroxaban Combined with Urokinase on LEDVT Treatment and Its Effects on Ultrasound Parameters

WANG Jia1, LI Xiaotian1, SONG Hao2   

  1. 1. School of Pharmacy, Zhengzhou University, Zhengzhou 450000, Henan, P. R. China;
    2. Jingpei Center, Pharmacy Department, Henan Provincial People's Hospital, Zhengzhou 450000, Henan, P. R. China
  • Received:2022-04-26 Published:2022-09-13

Abstract: This paper analyzed the therapeutic effect and ultrasound assessment of rivaroxaban combined with urokinase for thrombolysis in patients with lower extremity deep venous thrombosis (LEDVT). Selected 100 patients with LEDVT as research subjects, according to the method of random number table they were divided into the control group with 50 cases and the study group with 50 cases. The control group was treated with urokinase, and the study group was treated with rivaroxaban + urokinase to detect and compare the inflammatory cytokines, coagulation function indicators, ultrasound parameters level and clinical efficacy of the two groups. After treatment, The levels of Interleukin-18 (IL-18), C reactive protein (CRP), interleukin-6 (IL-6), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin time (TT), prothrombin time (PT), peak systolic velocity (PSV) and end diastolic velocity (EDV) were reduced, and the study group was lower than the control group. The RI levels of the two groups were increased after treatment, in addition, the study group was higher than the control group (P<0.05). Compared with the ineffective patients in research group, the effective patients have lower levels of PSV, EDV and higher level of RI were lower (P<0.05). The treatment response rate in research group was significantly higher than the control group (P<0.05). In conclusion, it could be seen that the inflammatory factors decreased and coagulation function improved for deep vein thrombosis after rivaroxaban and urokinase combined treatment, and the ultrasound parameters changed significantly after combined treatment. All these suggested that ultrasound could be used to evaluate thrombolysis effect in patients with LEDVT.

Key words: lower extremity deep venous thrombosis, urokinase, rivaroxaban, color doppler ultrasound