IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1195-1199.DOI: 10.7517/issn.1674-0475.220513

• Review and Articles • Previous Articles     Next Articles

Analysis of HFNC Therapeutic Effect and CT Parameters Changes in Elderly COPD Patients Complicated with Respiratory Failure

LIANG Jinpai1, ZHAO Hongling1, ZHANG Bing1, LIU Shuhong1, XIAO Cuijun1, YAN Xixin2, CHAI Shukun3, LIU Li4   

  1. 1. Department of Second Geriatrics, Hengshui People's Hospital, Hengshui 053000, Hebei, P. R. China;
    2. Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, P. R. China;
    3. Department of Respiratory Medicine, Shijiazhuang First Hospital, Shijiazhuang 050000, Hebei, P. R. China;
    4. Department of Endocrinology, The First Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, P. R. China
  • Received:2022-05-27 Published:2022-09-13

Abstract: This study investigated the changes and effects of CT quantitative parameters in elderly patients with chronic obstructive pulmonary disease (COPD) complicated with respiratory failure before and after nasal high flow humidification oxygen inhalation (HFNC). 200 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with mild respiratory failure were randomly divided into two groups with 100 cases in each group. All patients were received non-invasive ventilation, and on the basis the patients in the treatment group were treated with HFNC, and the patients in the control group were treated with low flow oxygen therapy. The blood gas parameters, maximum abnormal end inspiratory volume (Cvin), maximum abnormal end expiratory volume (Cvex), lung volume, lung transverse diameter and other CT quantitative parameters of the two groups were compared before and after treatment, and the treatment effects of the two groups were compared. After 72 hours of treatment, the PaO2, PaO2/FiO2 and SaO2 values in the treatment group were higher than those in the control group, and the PaCO2 values in the treatment group were lower than those in the control group, the differences were statistically significant (P<0.05). After treatment, the measured values of Cvin, Cvex, lung transverse diameter, LAA%-950insp, LAA%-856exp in the treatment group were lower than those in the control group (P<0.05). After treatment, the CAT score and mMRC score of the treatment group were lower than those of the control group (P<0.05). After one week of treatment, the effective rate of the treatment group was higher than that of the control group (P<0.05). The effect of transnasal HFNC on COPD patients complicated with respiratory failure is significant. CT lung scan can effectively observe the changes of lung function before and after transnasal HFNC treatment, which is of great significance for evaluating the clinical treatment effect.

Key words: chronic obstructive pulmonary disease, respiratory failure, non-invasive ventilation, nasal high-flow humidified oxygen inhalation, CT