IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1019-1023.DOI: 10.7517/issn.1674-0475.220516

• Review and Articles • Previous Articles     Next Articles

Changes of VOCAL Parameters and Hcy Levels in Patients with Gestational Hypertension

WANG Lingling1, GUO Zhiguo2, LU Limin3, LI Shuang1, REN Chunli4, CAO Xiuyan5, XIE Shoujun1, ZHENG Huachuan6   

  1. 1. Department of Laboratory, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
    2. Department of General Surgery, Weichang County Maternal and Child Health Hospital, Chengde 067450, Hebei, P. R. China;
    3. Department of Ultrasound, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
    4. Department of Obstetrics, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
    5. Department of Laboratory, Shuangluan District People's Hospital, Chengde 067000, Hebei, P. R. China;
    6. Central Laboratory, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China
  • Received:2022-05-27 Published:2022-09-13

Abstract: This paper investigated the changes of computer-assisted analysis of virtual organs (VOCAL) parameters and homocysteine (Hcy) levels in patients with gestational hypertension (PIH). 121 patients with gestational hypertension (PIH) were selected as the study group, and another 92 normal pregnant women in the same period were included as the control group. Both the two groups underwent VOCAL examination, and detected the Hcy expression by fully automated biochemical analyzer. The results showed that vascularity index(VI),flow index(FI), and vascularization flow index(VFI)in the study group were all lower than those in the control group, serum Hcy levels were higher than in the control group. FI, VI, VFI were negatively correlated with Hcy, and the AUC of combined diagnosis of PIH with FI, VI, VFI, and Hcy was better than that of single diagnosis (P<0.05). The incidence of adverse pregnancy outcome was higher in patients with low expression of VOCAL parameters than in those with high expression. The incidence of adverse pregnancy outcomes was lower in patients with high expression of Hcy than in patients with low expression, and both VOCAL parameters and Hcy were both factors influencing adverse pregnancy outcomes in patients with PIH (P<0.05). It can be seen that patients with PIH have abnormal expression of VOCAL parameters and Hcy, which has guiding significance for the diagnosis and treatment of the disease.

Key words: pregnancy induced hypertension, computer-aided analysis of virtual organs, homocysteine, pregnancy outcome, correlation