IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1308-1312.DOI: 10.7517/issn.1674-0475.220525

• Review and Articles • Previous Articles     Next Articles

Study of High Frequency Ultrasound Elastography Combined with Anti-TG and Anti-TPO in the Diagnosis of Benign and Malignant Thyroid Nodules

QI Yantao1, LIU Huiming2, LI Hongyu2, CHAI Jixin1, ZHANG Liuyang1, LI Bo1, AO Yazhou1   

  1. 1. Department of Thyroid Surgery, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China;
    2. Department of Physical Examination, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China
  • Received:2022-05-27 Published:2022-09-13

Abstract: This study analyzed the diagnostic value of high-frequency ultrasound elastography combined with anti-thyroglobulin antibody (Anti-TG) and anti-thyroid peroxidase (Anti-TPO) in the diagnosis of benign and malignant thyroid nodules. 55 patients with suspected thyroid nodules were selected as the research objects. According to pathological examination results, they were divided into the benign group with 30 cases and a malignant group with 25 cases. The levels of Anti-TG and Anti-TPO were detected by automatic chemiluminescence analyzer, and the correlation between high-frequency ultrasound elastography and Anti-TG and Anti-TPO was analyzed by Pearson correlation. Compared with benign patients, malignant patients had higher diastolic blood flow velocity (D), resistance index (RI) and pulsatility index (PI) (P<0.05). Compared with benign patients, Anti-TG and Anti-TPO were increased in malignant patients (P<0.05). D, RI and PI parameters were positively correlated with the expression levels of Anti-TG and Anti-TPO. Compared with the single diagnosis of D, RI and PI, the combination of the three items has higher diagnostic value for malignant thyroid nodules (P<0.001). High-frequency ultrasound elastography has high diagnostic value in patients with benign and malignant thyroid nodules, and is correlated with the patient's Anti-TG and Anti-TPO indicators, which can be used for the diagnosis of benign and malignant thyroid nodules.

Key words: positive and malignant thyroid nodules, high-frequency ultrasound elastography, antithyroglobulin antibodies, anti alpha peroxidase antibodies, diagnostic value