IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2022, Vol. 40 ›› Issue (5): 1226-1230.DOI: 10.7517/issn.1674-0475.220623

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Correlation between Carotid Plaque Characteristics and Serum Hcy, Cys-C, ApoA1 and UA in Patients with Ischemic Stroke Complicated with T2DM Assessed by CTA

JIN Zhaowei, MA Feilong, ZHANG Dandan, CAO Hongwei   

  1. Department of Medical Examination, Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, P. R. China
  • Received:2022-06-22 Published:2022-09-13

Abstract: This study investigated the relationship between carotid artery plaque characteristics and serum homocysteine (Hcy), cystatin C (Cys-C), apolipoprotein A1 (ApoA1) and uric acid (UA) levels in patients with ischemic stroke complicated with type 2 diabetes mellitus (T2DM) assessed by carotid CT angiography (CTA). 130 ischemic stroke patients with T2DM were selected as the case group, and 65 patients with pure T2DM were selected as the control group. The serum Hcy, Cys-C, ApoA1 and UA levels of the two groups were detected and compared. The case group underwent CTA examination, and the differences of the above indicators in patients with different carotid artery stenosis degrees and plaque characteristics were analyzed. The serum Hcy, Cys-C and UA levels in the case group were significantly higher than those in the control group, and the ApoA1 level in the case group was lower than that in the control group (P<0.05). The serum levels of Hcy, Cys-C and UA in the unstable plaque group were significantly higher than those in the stable plaque group, and the ApoA1 level in the unstable plaque group was lower than that in the stable plaque group (P<0.05). Serum UA levels in patients with severe stenosis were significantly higher than those in patients with mild-to-moderate stenosis, and ApoA1 levels in patients with severe stenosis were lower than those in patients with mild-to-moderate stenosis (P<0.05). CTA assessment can accurately assess the characteristics of carotid artery stenosis and plaque in patients with ischemic stroke complicated with T2DM, at the same time, the changes of Hcy, Cys-C, ApoA1 and UA levels are correlated with plaque characteristics and the degree of carotid artery stenosis.

Key words: ischemic stroke, type 2 diabetes, carotid plaque, CT angiography, homocysteine, cystatin C, apolipoprotein A1, uric acid