Fabrication of Biocompatible Nanofibrious Scaffold by Electrospun TiO2 and Methacrylated Hyaluronic Acid(MeHA)

doi:10.7517/j.issn.1674-0475.2016.03.281

Abstract

Abstract:

By observing the electron microscopy images, it is found that the bone of the body has abundant fiber micro-nano structure. Inspired by this observation, we designed bio-activating surface of titanium dioxide electrospun and constructed the fiber micro-nano structure at the same time which imitated bone surface. Considering the titanum dioxide(TiO₂) electrospun possesses light-triggered property and non-toxic, we adopted the "top-down" one step method and synthesized MeHA to bio-activated the surfae of TiO₂ electrospun, which was obtained through uv-irradiation(UV) by a simple way. Fourier infrared spectrum analysis showed that the surface of titanum dioxide(TiO₂) electrospun grafted hyaluronic acid molecules successfully. By fluorescence and scanning electron microscopy (SEM) analysis, it shows that mesenchymal stem cells can growth well on the modified surface of TiO₂ electrospun. This building method bio-activated the surface of TiO₂ electrospun and imitated the bone surface through micro-nano fiber topology. The TiO₂ electrospun can spin on different kinds of materials surface, so the surfaces of different materials would easily get bio-activated fiber surface structure which can be used for cell culture .These results suggested that TiO₂ electrospun modified with MeHA are more suitable for implants and have large clinical potential.

Key words: titanum dioxide electrospun, hyaluronic acid, ultraviolet initiated polymerization, cell culture

LIU Sidi, ZHANG Junhu. Fabrication of Biocompatible Nanofibrious Scaffold by Electrospun TiO₂ and Methacrylated Hyaluronic Acid(MeHA)[J]. Imaging Science and Photochemistry, 2016, 34(3): 281-287.

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Fabrication of Biocompatible Nanofibrious Scaffold by Electrospun TiO₂ and Methacrylated Hyaluronic Acid(MeHA)

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