Preparation of Resin-like Vitamin D3 by Micro-flow Photoreaction

doi:10.7517/j.issn.1674-0475.2017.04.027

Imaging Science and Photochemistry ›› 2017, Vol. 35 ›› Issue (5): 667-674.DOI: 10.7517/j.issn.1674-0475.2017.04.027

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Preparation of Resin-like Vitamin D₃ by Micro-flow Photoreaction

LI Chao, ZHOU Qianxiong, ZHANG Baowen, WANG Xuesong

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China

Received:2017-05-27 Revised:2017-06-15 Online:2017-09-15 Published:2017-09-15

Abstract

Abstract:

The key process in the synthesis of vitamin D₃ is the photochemical conversion from 7-dehydrocholesterol to pre-vitamin D₃, which is currently carried out in batch photoreactors and suffers from low conversion efficiency, recycle of unreacted 7-dehydrocholesterol, and long production period. Using micro-flow photoreactor instead of batch photoreactor, the conversion yield of 7-dehydrocholesterol may be increased from less than 30% to over 95%,allowing the photoreaction product to be directly used to prepare resin-like vitamin D₃ through a thermal isomerization reaction and shortening the production period greatly.

Key words: vitamin D₃, 7-dehydrocholesterol, pre-vitamin D₃, micro-flowphotoreactor

LI Chao, ZHOU Qianxiong, ZHANG Baowen, WANG Xuesong. Preparation of Resin-like Vitamin D₃ by Micro-flow Photoreaction[J]. Imaging Science and Photochemistry, 2017, 35(5): 667-674.

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Preparation of Resin-like Vitamin D₃ by Micro-flow Photoreaction

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[1]	ZHANG Dong, WU Li-zhu, ZHANG Li-ping, TUNG Chen-ho(TONG Zhen-he). PHOTOSENSITIZED OXIDATION OF 7-DEHYDROCHOLESTEROL BY NAFION-LOADED PLATINUM(Ⅱ) TERPYRIDYL ACETYLIDE COMPLEX [J]. Imaging Science and Photochemistry, 2003, 21(6): 405-411.
[2]	GAO Yun-yan, YOU Chang-jiang, CHEN Jin-ping, LI Yi. SYNTHESIS OF SILICA-ANCHORED SENSITIZER AND ITS APPLICATION IN THE PHOTOISOMERIZATION OF trans-VITAMIN D₃ TO cis-VITAMIN D₃ [J]. Imaging Science and Photochemistry, 2003, 21(1): 20-24.