Imaging Science and Photochemistry ›› 2017, Vol. 35 ›› Issue (1): 15-25.DOI: 10.7517/j.issn.1674-0475.2017.01.015

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Principle and Progress for the Surface Plasmon Resonance Sensor

WU Shikang   

  1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
  • Received:2016-12-01 Online:2017-01-15 Published:2017-01-15

Abstract:

Surface plasmon resonance (SPR) is a high sensitivity detection technology that was rapidly developed in recent years. It is a label-free method with the capability of real-time to measure quantitatively the binding affinity between foreign species and some receptor components located on chips. It is also used as an important tool for detecting relatively small amounts of materials interested. Due to the capability to study the kinetics of chemical reactions, this method possesses important significance for the studying of interaction between drugs and its ligand molecule for new drug development. Under this reason, extensive attention for this method has been exhibited. In this paper, the formation of SPR phenomenon and its principle, mechanism for using as a sensitive sensor and its improvement have been briefly introduced and discussed.

Key words: surface plasmon resonance (SPR), sensor, nanosphere lithography(NSL), noble metal nanoparticles, extraordinary optical transmission(EOT)