Imaging Science and Photochemistry ›› 2017, Vol. 35 ›› Issue (4): 574-580.DOI: 10.7517/j.issn.1674-0475.2017.04.019

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Synthesis of GelMA/PEGDA Hydrogel by UV Photopolymerization

WANG Yihu1,2, ZHANG Bing1, MA Ming1, LU Weipeng1, WANG Jianing1, GUO Yanchuan1   

  1. 1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China;
    2. University of Chinese Academy of Sciences, Beijing 100049, P. R. China
  • Received:2017-05-30 Revised:2017-06-12 Online:2017-07-15 Published:2017-07-15

Abstract:

To avoid the thermolability of physically cross-linked gelatin hydrogel and toxicity of chemically cross-linked gelatin hydrogel, double bonds were introduced to gelatin molecule chain by acrylation, and then gelatin methacrylamide(GelMA) and polyethylence glycol diacrylate(PEGDA) were cross-linked to hydrogels by the UV photopolymerization. The relationship between the quantity of methacrylic anhydride(MA) and degree of modification and physicochemical properties of GelMA/PEGDA were investigated and analyzed. The result indicated that more radicals could be released in the system when more PEGDA were added. So the activity and extent of crosslinking reaction was increased and hydrogel with much denser 3D network was formed. Cross-linked GelMA/PEGDA hydrogel have better thermal stability than cross-linked GelMA at 37 ℃. Cross-linked GelMA/PEGDA hydrogel can be used as scaffold materials of tissue engineering.

Key words: hydrogel, UV photopolymerization, gelatin methacrylamide, polyethylence glycol diacrylate