Nanomechanical Detection of Living Head and Neck Tissue Samplesby Atomic Force Microscopy

doi:10.7517/j.issn.1674-0475.2016.03.288

Imaging Science and Photochemistry ›› 2016, Vol. 34 ›› Issue (3): 288-296.DOI: 10.7517/j.issn.1674-0475.2016.03.288

Nanomechanical Detection of Living Head and Neck Tissue Samplesby Atomic Force Microscopy

WANG Zhou¹, LI Jing², GAO Jingwei², HAN Xinxiao², HUA Wenda², LIU Zhongqi¹, HAN Dong²

1. Peking Univercity Third Hospital, Beijing 100191, P.R.China;
2. National Center for Nanoscience and Technology, Beijing 100190, P.R.China

Received:2016-04-09 Revised:2016-04-25 Online:2016-05-15 Published:2016-05-15

Abstract

Abstract:

The biomechanical change in tumor and its microenvironment is one of the basic biological characteristics, which plays a key role in the processin oncogenesis and development of tumor. The stiffness is a more important biomechanical feature. In this paper, AFM is employed to address the nanomechanical properties of the living tissue sample from head and neck. Furthermore, the stiffness information is converted into the stiffness distribution. Then the curvature of the interface among different stiffness regions is analyzed.In situ analysis of mechanical properties of living head and neck tissue samples is expected to provide a diagnosis of benign and malignant lesions of the head and neck tissues.

Key words: head and neck tissues, nanobiomechanics, stiffness, atomic force microscopy, curvature

WANG Zhou, LI Jing, GAO Jingwei, HAN Xinxiao, HUA Wenda, LIU Zhongqi, HAN Dong. Nanomechanical Detection of Living Head and Neck Tissue Samplesby Atomic Force Microscopy[J]. Imaging Science and Photochemistry, 2016, 34(3): 288-296.

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Nanomechanical Detection of Living Head and Neck Tissue Samplesby Atomic Force Microscopy

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